Creating a free account will enable you to subscribe to our daily and weekly email newsletters, as well as customize your reading experience to show only the categories most relevant to you.
Signing up only take a few minutes, so why not give it a try and see what you've been missing out on.
In the latest in a series of experiments testing the use of stem cells to treat neurological disease, researchers at Henry Ford Hospital have shown for the first time that microscopic material in the cells offers a "robust" treatment for crippling stroke.
"In this study we pioneered a totally new treatment for stroke, and possibly for all neurological disease," says Michael Chopp, Ph.D., scientific director of the Henry Ford Neuroscience Institute.
The new study is published online in the current issue of Journal of Cerebral Blood Flow and Metabolism.
It focused on exosomes, blister-like microscopic "bubbles" that once were thought to carry and get rid of "old" proteins that were no longer needed by the body. After they were recently found to also carry RNA, whole new fields of study were suggested - including the pioneering work at Henry Ford.
The research team found that after inducing stroke in lab rats, injecting exosomes containing this genetic material into their blood prompted remodeling of the affected brain, including increased production of new brain cells, blood vessels and neural rewiring. Together, these effects significantly improved neurological function that had been impaired by stroke.
Using bone marrow from the adult rats, the researchers extracted stem cells - specifically mesenchymal cells, or MSCs - that were then employed to generate exosomes.
The researchers induced stroke by occluding an artery in the brain of each rat to block blood flow for two hours. Twenty-four hours later, they injected the exosomes into a vein in each rat's tail.
The rats' physical agility and neurological responses were tested before stroke and after treatment with the exosomes, and the results were compared.
"All rats showed severe functional loss one day after treatment, but gradual and eventually significant improvement during the four-week period that followed," Dr. Chopp says. "This discovery provides a novel treatment for stroke, and possibly other neurological diseases."
Dr. Chopp and Henry Ford researchers earlier found that the beneficial effects of treatment of stroke with bone marrow cells are attributed to their production and release of exosomes. In addition, using a similar treatment with exosomes from bone marrow stem cells significantly reduced a particularly resistant form of malignant brain tumor in living lab rats.
Funding source: NIH grants R01AG037506 (MC), R01 NS066041 (YL), and R01NS081189 (HX)
Journal of Cerebral Blood Flow & Metabolism advance online publication 21 August 2013; doi: 10.1038/jcbfm.2013.152
Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our Stroke category page for the latest news on this subject.
Please use one of the following formats to cite this article in your essay, paper or report:
Henry Ford Health System. "Novel treatment for stroke and possibly other neurological diseases." Medical News Today. MediLexicon, Intl., 29 Aug. 2013. Web.
8 Dec. 2013. <http://www.medicalnewstoday.com/releases/265291>
Henry Ford Health System. (2013, August 29). "Novel treatment for stroke and possibly other neurological diseases." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
If you write about specific medications, operations, or procedures please do not name healthcare professionals by name.
For any corrections of factual information, or to contact the our editorial team, please use our feedback form. Please send any medical news or health news press releases to:
Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.
This page was printed from: http://www.medicalnewstoday.com/releases/265291.php
Visit www.medicalnewstoday.com for medical news and health news headlines posted throughout the day, every day.
© 2004-2013 All rights reserved. MNT (logo) is the registered trade mark of MediLexicon International Limited.