Creating a free account will enable you to subscribe to our daily and weekly email newsletters, as well as customize your reading experience to show only the categories most relevant to you.
Signing up only take a few minutes, so why not give it a try and see what you've been missing out on.
Lumbar disc degeneration (LDD) is characterized by pain in the lumbar region of the spine as a result of a compromised disc. LDD is fairly common and thought to be the result of both environmental and genetic risk factors; however, the genetic factors that promote LDD are largely unknown.
In this issue of the Journal of Clinical Investigation, Danny Chan and colleagues at the University of Hong Kong found mutations that reduced production of carbohydrate sulfotransferase 3 (CHST3) were associated with early-onset LDD. Mutations in families with LDD were mapped to the 3' untranslated region of the CHST3 gene, which contained a microRNA binding site.
The authors determined that LDD-associated mutations in the 3' untranslated region enhanced microRNA binding, resulting in decreased CHST3 expression. Furthermore, patients with early-onset LDD had decreased CHST3 mRNA levels in interevertebral discs.
This study indicates that LDD development can be predicted by decreased CHST3 expression.
Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our Back Pain category page for the latest news on this subject.
Please use one of the following formats to cite this article in your essay, paper or report:
Journal of Clinical Investigation. "Identification of early-onset lumbar disc degeneration-associated mutation." Medical News Today. MediLexicon, Intl., 10 Oct. 2013. Web.
8 Dec. 2013. <http://www.medicalnewstoday.com/releases/267187>
Journal of Clinical Investigation. (2013, October 10). "Identification of early-onset lumbar disc degeneration-associated mutation." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
If you write about specific medications, operations, or procedures please do not name healthcare professionals by name.
For any corrections of factual information, or to contact the our editorial team, please use our feedback form. Please send any medical news or health news press releases to:
Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.
This page was printed from: http://www.medicalnewstoday.com/releases/267187.php
Visit www.medicalnewstoday.com for medical news and health news headlines posted throughout the day, every day.
© 2004-2013 All rights reserved. MNT (logo) is the registered trade mark of MediLexicon International Limited.