Creating a free account will enable you to subscribe to our daily and weekly email newsletters, as well as customize your reading experience to show only the categories most relevant to you.
Signing up only take a few minutes, so why not give it a try and see what you've been missing out on.
This work, published on the website of Nature Communications, concerns the role of one protein which is common to these parasites. Called AMA1, it has been at the heart of many years' research on upgrading treatments, such as trying out vaccination against malaria. However, the present authors have reservations about the success of therapeutic strategies which rely solely on the blockage of AMA1, by demonstrating that the malaria and toxoplasmosis parasites, without the protein, can develop normally.
With 1 million victims every year, malaria is the most dangerous parasitic disease in the world, while Toxoplasmosis, often asymptomatic, represents a danger to pregnant women and those with weak immune systems.
Plasmodium falciparum and Toxoplasma gondii, the parasites responsible respectively for malaria and toxoplasmosis, belong to the group of Apicomplexa. This group, wholly composed of parasite organisms, share a common protein called AMA1. This protein is described in many studies as being indispensable for entry into the cells they infect. As a result, since its discovery, many research teams have made AMA1 a major therapeutic target in the improvement of treatments.
However, a collaboration between the teams of Robert Ménard at the Institut Pasteur in Paris, Isabelle Tardieux at the Institut Cochin, and Markus Meissner at the University of Glasgow, has just shown that Plasmodium falciparum and Toxoplasma gondii can survive and multiply in the infected cells totally without the action of AMA1. This discovery will have an important impact on the search for a treatment for malaria and toxoplasmosis.
The team generated parasites totally lacking AMA1 thanks to a technique of "reverse genetics", never before used in the field. The scientists thus made the following observations: in the absence of AMA1, Plasmodium falciparum, at all human stages (blood and liver), is capable of invading the host cells. The same is true of one of the two human stages of Toxoplasma gondii. On the other hand, for both parasites, the attachment to the host cells, which precedes cellular invasion, is affected.
As a result, the scientists have deduced that AMA1, short of being indispensable to the process of cellular invasion, is in fact a protein implicated in the adhesion to host cells.
As a result of their observations, the researchers are recommending ways of optimising research which targets AMA1 with a view to improving treatments. In particular, they suggest that therapeutic strategies should be based on the blockage of other proteins complementary to AMA1.
Daniel Y. Bargieri, Nicole Andenmatten, Vanessa Lagal, Sabine Thiberge, Jamie A. Whitelaw, Isabelle Tardieux, Markus Meissner & Robert Ménard. Nature Communications 4, Article number: 2552 doi:10.1038/ncomms3552 Published 10 October 2013
Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our Tropical Diseases category page for the latest news on this subject.
Please use one of the following formats to cite this article in your essay, paper or report:
University of Glasgow. "Researchers seek ways to optimise research which targets AMA1, aiming to improve treatments for malaria, toxoplasmosis." Medical News Today. MediLexicon, Intl., 14 Oct. 2013. Web.
9 Dec. 2013. <http://www.medicalnewstoday.com/releases/267341>
University of Glasgow. (2013, October 14). "Researchers seek ways to optimise research which targets AMA1, aiming to improve treatments for malaria, toxoplasmosis." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
If you write about specific medications, operations, or procedures please do not name healthcare professionals by name.
For any corrections of factual information, or to contact the our editorial team, please use our feedback form. Please send any medical news or health news press releases to:
Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.
This page was printed from: http://www.medicalnewstoday.com/releases/267341.php
Visit www.medicalnewstoday.com for medical news and health news headlines posted throughout the day, every day.
© 2004-2013 All rights reserved. MNT (logo) is the registered trade mark of MediLexicon International Limited.