Creating a free account will enable you to subscribe to our daily and weekly email newsletters, as well as customize your reading experience to show only the categories most relevant to you.
Signing up only take a few minutes, so why not give it a try and see what you've been missing out on.
Scientists from the Helmholtz Zentrum Munchen in cooperation with the University of Cincinnati, USA, have discovered that the placement of a non-permeable tube in the small intestine leads to reduced nutrient absorption and consequently to reduced obesity and enhanced glucose metabolism. These findings are published in the current issue of the British medical journal Gut.
Bariatric surgeries, such as a gastric bypass, are currently the most effective anti-obesity therapies. They also lead to a reduced insulin resistance. However, the pitfall of these surgical interventions is that they are highly invasive and often permanent procedures. An international team of scientists led by Dr. Kirk Habegger, Metabolic Disease Institute, University of Cincinnati, and Prof. Dr. Matthias Tschöp, Scientific Director of the Helmholtz Diabetes Center (HDC) at the Helmholtz Zentrum München (HMGU), Partner of the German Center for Diabetes Research (DZD), have now developed an equally efficient but less invasive surgical method, thus paving the way for the development of novel safe and efficient anti-obesity therapies.
In their study, a flexible tube, called a DES (duodenal-endoluminal sleeve), was placed in the small intestine. Tschöp, Habegger, and colleagues observed that this intervention in an animal model potently corrects obesity while improving glucose metabolism. The metabolic benefits of this novel surgical intervention seem to be mediated via reduced nutrient absorption in the intestinal lumen and reactive mucous membrane growth in the other intestinal sections, a shift which may lead to improved nutrient utilization. The intervention carries the great advantage that it is less invasive and removable at any time.
The method is consequently seen as a promising approach to treat obesity and diabetes. Further studies now aim to clarify which influence this novel surgical technique has on the complex neuroendocrine network that controls energy metabolism. The long-term goal based on such better understanding is to optimize devices to the level where they can be used successfully in humans, potentially in combination with hormone based drug therapies.
The numerous conditions associated with overweight and obesity, such as type 2 diabetes, are among the major widespread diseases in Germany. They are the focus of the research at the Helmholtz Zentrum München.
Original publication: Habegger, KM. et al. (2013), GLP-1R Agonism Enhances Adjustable Gastric Banding in Diet-Induced Obese Rats.,
Habegger KM, Kirchner H, Yi CX, Heppner KM, Sweeney D, Ottaway N, Holland J, Amburgy S, Raver C, Krishna R, Müller TD, Perez-Tilve D, Pfluger PT, Obici S, Dimarchi RD, D'Alessio DA, Seeley RJ, Tschöp MH. Diabetes. 2013 Sep;62(9):3261-7. doi: 10.2337/db13-0117. Epub 2013 Jun 17.
Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our Obesity / Weight Loss / Fitness category page for the latest news on this subject.
Please use one of the following formats to cite this article in your essay, paper or report:
München, Helmholtz Zentrum. "Intestinal barrier sleeves, a promising approach for the treatment of obesity and diabetes." Medical News Today. MediLexicon, Intl., 14 Oct. 2013. Web.
7 Dec. 2013. <http://www.medicalnewstoday.com/releases/267343>
München, H. (2013, October 14). "Intestinal barrier sleeves, a promising approach for the treatment of obesity and diabetes." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
If you write about specific medications, operations, or procedures please do not name healthcare professionals by name.
For any corrections of factual information, or to contact the our editorial team, please use our feedback form. Please send any medical news or health news press releases to:
Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.
This page was printed from: http://www.medicalnewstoday.com/releases/267343.php
Visit www.medicalnewstoday.com for medical news and health news headlines posted throughout the day, every day.
© 2004-2013 All rights reserved. MNT (logo) is the registered trade mark of MediLexicon International Limited.