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Prostate cancer has variable manifestations, ranging from relatively benign localized tumors to widespread life-threatening metastases.
In this issue of the Journal of Clinical Investigation, Srinivasan Yegnasubramanian and colleagues at Johns Hopkins University track the development of lethal prostate cancer in a patient.
Using tissue samples taken throughout the progression of the cancer, the authors identified the origin of the lethal clone. Surprisingly, in this case the lethal clone originated from a small, low-grade foci in the primary tumor and not from the larger high-grade region of the tumor.
In the accompanying commentary, Rose Brannon and Charles Sawyers of Memorial Sloan-Kettering Cancer Center discuss the importance of individual case studies and how a comprehensive database of such studies is needed to identify common patterns in cancer progression.
ACCOMPANYING COMMENTARY TITLE: "N of 1" case reports in the era of whole-genome sequencing
Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our Prostate / Prostate Cancer category page for the latest news on this subject.
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