Creating a free account will enable you to subscribe to our daily and weekly email newsletters, as well as customize your reading experience to show only the categories most relevant to you.
Signing up only take a few minutes, so why not give it a try and see what you've been missing out on.
In a study published in the open-access journal The Lancet Global Health, the Drugs for Neglected Diseases initiative (DNDi) and other researchers report a persistent deficiency in truly new therapeutics for neglected diseases, despite nominal progress and an acceleration in research and development (R&D) efforts. This continued 'fatal imbalance' in medical R&D points to the urgent need to develop and deliver groundbreaking new treatments for the world's poorest and most neglected patients.
Researchers from DNDi, Médecins Sans Frontières/Doctors Without Borders (MSF), the Special Programme for Research and Training in Tropical Diseases (WHO-TDR), and three universities (University Hospital of Grenoble, France; Joseph Fourier University, France; University of Oxford, UK) found that of the 850 new drugs and vaccines approved for all diseases, 4% (37) were for neglected diseases, defined broadly as those prevalent primarily in poor countries: malaria, tuberculosis, 17 neglected tropical diseases (NTDs) as defined by the World Health Organization (WHO), 11 diarrheal diseases, and 19 other diseases of poverty, excluding HIV/AIDS. Globally these neglected diseases represent an 11% health burden, based on a recent assessment of 2010 disability-adjusted life-years (DALYs).
Most newly developed therapeutic products were repurposed versions of existing drugs. Of the 336 brand-new drugs (new chemical entities, or NCEs) approved for all diseases in 2000-2011, only four, or 1%, were for neglected diseases; three were for malaria, and one for diarrheal disease. None were for any of the 17 WHO-listed NTDs.
'While drug and vaccine development shows signs of acceleration for neglected diseases, we must keep pushing to keep these diseases on the international policy agenda and move quickly to deliver truly transformative, life-saving treatments', said Dr Bernard Pécoul, Executive Director of DNDi.
'Although strides have been made in the last decade, we still see deadly gaps in new medicines for some of the world's least visible patients', said Dr Nathalie Strub-Wourgaft, Medical Director of DNDi. 'We need to get more treatment candidates, NCEs or existing ones for repurposing, into and through the R&D pipeline to fundamentally change the way we manage these diseases.'
'Our patients are still waiting for true medical breakthroughs', said Dr Jean-Hervé Bradol of MSF, a co-author of the study. 'People are still suffering and dying from these diseases, and healthcare providers must be able to offer all patients - irrespective of their ability to pay - the best treatment possible. Only then will we say that we have made progress.'
Authors: Dr Belen Pedrique MD, Nathalie Strub-Wourgaft MD, Claudette Some PharmD, Piero Olliaro MD, Patrice Trouiller PharmD, Nathan Ford PhD, Bernard Pécoul MD, Jean-Hervé Bradol MD
The Lancet Global Health, Early Online Publication, 24 October 2013 doi:10.1016/S2214-109X(13)70078-0
Drugs for Neglected Diseases initiative (DNDi)
Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our Pharma Industry / Biotech Industry category page for the latest news on this subject.
Please use one of the following formats to cite this article in your essay, paper or report:
ugs for Neglected Diseases initiative. "Deadly gaps persist in new drug development for neglected diseases." Medical News Today. MediLexicon, Intl., 30 Oct. 2013. Web.
8 Dec. 2013. <http://www.medicalnewstoday.com/releases/268044>
ugs for Neglected Diseases initiative. (2013, October 30). "Deadly gaps persist in new drug development for neglected diseases." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
If you write about specific medications, operations, or procedures please do not name healthcare professionals by name.
For any corrections of factual information, or to contact the our editorial team, please use our feedback form. Please send any medical news or health news press releases to:
Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.
This page was printed from: http://www.medicalnewstoday.com/releases/268044.php
Visit www.medicalnewstoday.com for medical news and health news headlines posted throughout the day, every day.
© 2004-2013 All rights reserved. MNT (logo) is the registered trade mark of MediLexicon International Limited.