Creating a free account will enable you to subscribe to our daily and weekly email newsletters, as well as customize your reading experience to show only the categories most relevant to you.
Signing up only take a few minutes, so why not give it a try and see what you've been missing out on.
New research indicates that a disruption of brain signals for reward and punishment contributes to increased pain sensitivity, known as hyperalgesia, in fibromyalgia patients. Results published in Arthritis & Rheumatism, a journal of the American College of Rheumatology, suggest that this altered brain processing might contribute to widespread pain and lack of response to opioid therapy in patients with fibromyalgia.
Fibromyalgia is a chronic, musculoskeletal syndrome characterized by widespread joint and muscle pain along with other symptoms such as fatigue, sleep disturbances, and cognitive difficulty. Previous research estimates that fibromyalgia affects 3.4% of women and 0.5% of men in the U.S. Prevalence of this pain disorder increases with age, affecting more than 7% of women between 60 and 79 years of age.
"In patients with fibromyalgia there is an alteration in the central nervous system pain processing and a poor response to topical pain treatments, trigger point injections and opioids," said lead author Dr. Marco Loggia from Massachusetts General Hospital and Harvard Medical School in Boston. "Our study examines the disruption of brain function involved in the individual experience of pain anticipation and pain relief."
For the present study, the research team enrolled 31 patients with fibromyalgia and 14 healthy controls. Functional magnetic resonance imaging (MRI) and cuff pressure pain stimuli on the leg were performed on all subjects. During the MRI, participants received visual cues alerting them of impending pain onset (pain anticipation) and pain offset (relief anticipation).
Results show that during pain anticipation and relief, fibromyalgia patients displayed less robust response within brain regions involved in sensory, affective, cognitive and pain regulating processes. The ventral tegmental area (VTA) - a group of neurons in the center of the brain involved in the processing of reward and punishment - displayed activation during pain anticipation and stimulation, but deactivation during anticipation of relief in healthy controls. In contrast, VTA responses during periods of pain, and anticipation of pain and relief, in fibromyalgia patients were significantly reduced or inhibited.
Dr. Loggia concludes, "Our findings suggest that fibromyalgia patients exhibit altered brain responses to punishing and rewarding events, such as expectancy of pain and relief of pain. These observations may contribute to explain the heightened sensitivity to pain, as well as the lack of effectiveness of pain medications such as opioids, observed in these patients. Future studies should further investigate the neurochemical basis underlying these dysfunctions."
This research was supported by the National Center for Complementary and Alternative Medicine (NCCAM), National Institutes of Health (NIH) grants (R01-AT004714, P01- AT002048, P01-AT006663, R01-AT005280; R01-AG034982, R21-AR057920).
Authors: Marco L. Loggia, Chantal Berna, Jieun Kim, Christine M. Cahalan, Randy L. Gollub, Ajay D. Wasan, Richard E. Harris, Robert R. Edwards and Vitaly Napadow.
Arthritis & Rheumatism; Published Online: November 5, 2013 - DOI: 10.1002/art.38191
Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our Fibromyalgia category page for the latest news on this subject.
Please use one of the following formats to cite this article in your essay, paper or report:
Wiley. "Pleasure and pain brain signals disrupted in fibromyalgia patients." Medical News Today. MediLexicon, Intl., 5 Nov. 2013. Web.
9 Dec. 2013. <http://www.medicalnewstoday.com/releases/268334>
Wiley. (2013, November 5). "Pleasure and pain brain signals disrupted in fibromyalgia patients." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
If you write about specific medications, operations, or procedures please do not name healthcare professionals by name.
For any corrections of factual information, or to contact the our editorial team, please use our feedback form. Please send any medical news or health news press releases to:
Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.
This page was printed from: http://www.medicalnewstoday.com/releases/268334.php
Visit www.medicalnewstoday.com for medical news and health news headlines posted throughout the day, every day.
© 2004-2013 All rights reserved. MNT (logo) is the registered trade mark of MediLexicon International Limited.