A hybrid heart valve created from thin and highly elastic mesh embedded within layers of human cells was strong and durable in a study presented at the American Heart Association's Scientific Sessions 2013.
Researchers created a three-dimensional cell culture by coating a scaffold of nickel-titanium alloy (Nitinol), used for devices that require flexibility and motion, with layers of smooth muscle, connective tissue and lining cells.
The valves performed well in a heart simulator, opening and closing under various pressures and remaining stable and strong throughout the tests.
A durable, regenerating hybrid heart valve would be an important advance because previous attempts to create tissue-engineered heart valves from patients' cells have been unsatisfactory.
All the prior methods entail significant limitations due to structural vulnerability, short-term functionality and mechanical properties of the tissue-engineered valves.