Creating a free account will enable you to subscribe to our daily and weekly email newsletters, as well as customize your reading experience to show only the categories most relevant to you.
Signing up only take a few minutes, so why not give it a try and see what you've been missing out on.
A Massachusetts General Hospital (MGH)-led research team has identified an immune cell protein that is critical to setting off the body's initial response against viral infection. The report that will be published in an upcoming issue of Nature Immunology and is receiving early online release describes finding that a protein called GEF-H1 is essential to the ability of macrophages - major contributors to the innate immune system - to respond to viral infections like influenza.
"The detection of viral genetic material inside an infected cell is critical to initiating the responses that signal the immune system to fight an infection and prevent its spread throughout the body," says Hans-Christian Reinecker, MD, of the Center for the Study of Inflammatory Bowel Disease in the MGH Gastrointestinal Unit, senior author of the report. "Our findings indicate that GEF-H1 may control immune responses against a wide variety of RNA and DNA viruses that pose a threat to human health."
The body's first line of defense against infection, the innate immune system rapidly responds to invading pathogens by mobilizing white blood cells, chemical factors called cytokines and antimicrobial peptides. When viruses invade cells, they often move towards the nucleus in order to replicate and sometimes to integrate their own genetic material into that of the host cell, traveling along structures called microtubules that cells use for internal protein transport. But how microtubule-based movement of viral components contributes to induction of the immune response has been unknown.
GEF-H1 is known to bind to microtubules, and previous research indicated that it has a role in immune recognition of bacteria. A series of experiments by Reinecker's team found that GEF-H1 is expressed in macrophages - key components of the innate immune system - and activated in response to viral RNA and that it controls the expression of beta interferon and other cytokines. Mice in which expression of GEF-H1 was knocked out were unable to mount an effective immune response to influenza A and to encephalomyocarditis, a virus that causes several types of infection in animals.
"The sensing of intracellular viral nucleic acids for induction of interferons is so important that many viruses, including influenza A, have evolved specific strategies to interfere with activation of the interferon defense system," says Reinecker, an associate professor of Medicine at Harvard Medical School. "We are hopeful that this discovery will allow the development of new strategies to curtail viral mechanisms that impede the immune responses to infections that are often associated with high mortality rates."
The co-lead authors of the Nature Immunology report are Hao-Sen Chiang, PhD, and Yun Zhao, MD, PhD, MGH Gastrointestinal Unit. Additional co-authors are Joo-Hye Song, PhD, Song Liu, MD, Megha Basavappa and Kate Jeffrey, PhD, MGH Gastrointestinal Unit; Ninghai Wang, MD, PhD, and Cox Terhorst, Beth Israel Deaconess Medical Center; and Arlene Sharpe, MD, PhD, Harvard Medical School. The study was supported by National Institutes of Health grants AI093588, DK-068181, DK-033506, 630 DK-043351 and DK-52510.
Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our Immune System / Vaccines category page for the latest news on this subject.
Please use one of the following formats to cite this article in your essay, paper or report:
Hospital, Massachusetts General. "Protein essential for immune recognition, response to viral infection identified." Medical News Today. MediLexicon, Intl., 26 Nov. 2013. Web.
9 Mar. 2014. <http://www.medicalnewstoday.com/releases/269296>
Hospital, M. (2013, November 26). "Protein essential for immune recognition, response to viral infection identified." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
If you write about specific medications, operations, or procedures please do not name healthcare professionals by name.
For any corrections of factual information, or to contact our editorial team, please use our feedback form. Please send any medical news or health news press releases to:
Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.
This page was printed from: http://www.medicalnewstoday.com/releases/269296.php
Visit www.medicalnewstoday.com for medical news and health news headlines posted throughout the day, every day.
© 2004-2014 All rights reserved. MNT (logo) is the registered trade mark of MediLexicon International Limited.