Creating a free account will enable you to subscribe to our daily and weekly email newsletters, as well as customize your reading experience to show only the categories most relevant to you.
Signing up only take a few minutes, so why not give it a try and see what you've been missing out on.
Dl-3n-butylphthalide can effectively treat cerebral ischemia; however, the mechanisms underlying the effects of dl-3n-butylphthalide on microcirculation disorders following diffuse brain injury remain unclear.
According to a study by Prof. Jianmin Li and team from Hebei United University of China, models of diffuse brain injury were established in Sprague-Dawley rats with the vertical impact method, and dl-3n-butylphthalide at 80 and 160 mg/kg was given via intraperitoneal injection immediately after diffuse brain injury.
After administration of dl-3n-butylphthalide, reduced cerebral ultrastructure damage, increased vascular density and cerebral blood flow, and improved motor and sensory functions were observed.
These findings, published in Neural Regeneration Research (Vol. 8, No. 28, 2013), demonstrate that dl-3n-butylphthalide may have protective effects against diffuse brain injury by ameliorating microcirculation disorder and reducing blood-brain barrier damage and cerebral edema.
Article: " Protective effects of dl-3n-butylphthalide against diffuse brain injury " by Yaning Zhao1, Jianmin Li2, Pan Zhang1, Changxiang Chen1, Shuxing Li1 (1 College of Rehabilitation, Hebei United University, Tangshan 063000, Hebei Province, China; 2 Affiliated Hospital of Hebei United University, Tangshan 063000, Hebei Province, China)
Zhao YN, Li JM, Zhang P, Chen CX, Li SX. Protective effects of dl-3n-butylphthalide against diffuse brain injury. Neural Regen Res. 2013;8(28):2615-2624.
Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our Stroke category page for the latest news on this subject.
Please use one of the following formats to cite this article in your essay, paper or report:
Research, Neural Regeneration. "Treating cerebral ischemia using dl-3n-butylphthalide." Medical News Today. MediLexicon, Intl., 1 Dec. 2013. Web.
10 Mar. 2014. <http://www.medicalnewstoday.com/releases/269440>
Research, N. (2013, December 1). "Treating cerebral ischemia using dl-3n-butylphthalide." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
If you write about specific medications, operations, or procedures please do not name healthcare professionals by name.
For any corrections of factual information, or to contact our editorial team, please use our feedback form. Please send any medical news or health news press releases to:
Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.
This page was printed from: http://www.medicalnewstoday.com/releases/269440.php
Visit www.medicalnewstoday.com for medical news and health news headlines posted throughout the day, every day.
© 2004-2014 All rights reserved. MNT (logo) is the registered trade mark of MediLexicon International Limited.