Creating a free account will enable you to subscribe to our daily and weekly email newsletters, as well as customize your reading experience to show only the categories most relevant to you.
Signing up only take a few minutes, so why not give it a try and see what you've been missing out on.
Even if the obesity trend cannot be reversed, here's hope that it's partner in crime - diabetes - might be thwarted. New research published in the December 2013 issue of The FASEB Journal shows how a recently discovered human peptide, called humanin, could lead to powerful new treatments for some people living with diabetes. That's because research in mice and rats shows that a humanin analogue (a peptide molecularly similar to humanin) increases insulin secretion leading to an increase in glucose metabolism within beta cells.
"Diabetes is a major disease that is expected to affect more than 500 million people in the next two decades," said Radhika Muzumdar, M.D., study author from the Departments of Pediatrics and Medicine in the Divisions of Endocrinology and Geriatrics at Children's Hospital at Montefiore at the Albert Einstein College of Medicine in Bronx, New York. "Humanin could be a potential weapon in our arsenal in the fight against this global problem."
To make this discovery, Muzumdar and colleagues tested the effects of humanin on insulin secretion in rats and mice; in groups of cells called islets from the pancreas that contain beta cells; and in cultured mouse beta cell lines. In rats, administration of a humanin analog increased insulin levels in the blood in response to high blood glucose levels. The humanin analog increased insulin secretion in islets from both normal mice as well as islets from diabetic mice. In the next step, researchers confirmed that humanin increases insulin secretion in isolated beta cells. The work also demonstrated that this was closely linked to energy production from metabolism of glucose in beta cells. In addition, when the metabolism of glucose in beta cells was blocked, humanin did not increase insulin secretion. Finally, humanin levels naturally decline with age, suggesting that humanin or its analogues may be benefit patients with other conditions as well, such as stroke, heart disease and Alzheimer's.
"As global obesity remains at very high levels, so does diabetes," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "This report identifies a promising compound that could have a dramatic effect on public health throughout the world."
Regina Kuliawat, Laura Klein, Zhenwei Gong, Marianna Nicoletta-Gentile, Anjana Nemkal, Lingguang Cui, Claire Bastie, Kai Su, Derek Huffman, Manju Surana, Nir Barzilai, Norman Fleischer, and Radhika Muzumdar Potent humanin analog increases glucose-stimulated insulin secretion through enhanced metabolism in the β cell. FASEB J December 2013 27:4890-4898; doi:10.1096/fj.13-231092
Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our Diabetes category page for the latest news on this subject.
Please use one of the following formats to cite this article in your essay, paper or report:
Federation of American Societies for Experimental. "Potential new treatment for diabetes following discovery of humanin." Medical News Today. MediLexicon, Intl., 4 Dec. 2013. Web.
24 Apr. 2014. <http://www.medicalnewstoday.com/releases/269595>
Federation of American Societies for Experimental. (2013, December 4). "Potential new treatment for diabetes following discovery of humanin." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
If you write about specific medications, operations, or procedures please do not name healthcare professionals by name.
For any corrections of factual information, or to contact our editorial team, please use our feedback form. Please send any medical news or health news press releases to:
Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.
This page was printed from: http://www.medicalnewstoday.com/releases/269595.php
Visit www.medicalnewstoday.com for medical news and health news headlines posted throughout the day, every day.
© 2004-2014 All rights reserved. MNT is the registered trade mark of MediLexicon International Limited.