Creating a free account will enable you to subscribe to our daily and weekly email newsletters, as well as customize your reading experience to show only the categories most relevant to you.
Signing up only take a few minutes, so why not give it a try and see what you've been missing out on.
Children's National researcher, Javad Nazarian, PhD, authored a new study entitled, "Comparative Multidimensional Molecular Analyses of Pediatric Diffuse Intrinsic Pontine Glioma Reveals Distinct Molecular Subtypes." The study found, for the first time, two distinct subtypes in pediatric diffuse intrinsic pontine gliomas (DIPG). It was published online in Acta Neuropathologica, a leading journal on pathology and pathogenesis of neurological disease.
This project was the first time researchers conducted a detailed analysis of proteome, transcriptome, methylome, and Histone H3 mutation profiles of DIPG specimens. One of the major results of the study was the discovery of two distinct subtypes of DIPGs and the identification of potential molecular pathways that lead to poorer overall survival of patients with histone 3 mutations.
DIPG is an aggressive tumor of the brainstem that cannot be surgically removed and is typically not biopsied due to the invasiveness of the procedure. For these reasons, a lack of tissue samples have contributed to a limited understanding of the tumor biology and hindered the development of treatments to improve survival rates.
"Pediatric DIPGs are almost always lethal, and most children do not survive beyond 18 months with this type of tumor," said Dr. Nazarian. "Our results have shown that a multidimensional molecular analysis can contribute to our understanding of DIPGs and guide future research for developing therapeutics."
Further study and a larger cohort of DIPG specimens are needed to identify all possible subtypes of DIPGs. Children's Research Institute (CRI) at Children's National Health System has generated the only published data on protein profiling of DIPGs. This is the third study on DIPG published by CRI.
Acta Neuropathologica December 2013 DOI 10.1007/s00401-013-1218-2
Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our Neurology / Neuroscience category page for the latest news on this subject.
Please use one of the following formats to cite this article in your essay, paper or report:
Children's National Medical Center. "Researcher studies pediatric brain stem tumors." Medical News Today. MediLexicon, Intl., 5 Dec. 2013. Web.
23 Apr. 2014. <http://www.medicalnewstoday.com/releases/269695>
Children's National Medical Center. (2013, December 5). "Researcher studies pediatric brain stem tumors." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
If you write about specific medications, operations, or procedures please do not name healthcare professionals by name.
For any corrections of factual information, or to contact our editorial team, please use our feedback form. Please send any medical news or health news press releases to:
Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.
This page was printed from: http://www.medicalnewstoday.com/releases/269695.php
Visit www.medicalnewstoday.com for medical news and health news headlines posted throughout the day, every day.
© 2004-2014 All rights reserved. MNT is the registered trade mark of MediLexicon International Limited.