Creating a free account will enable you to subscribe to our daily and weekly email newsletters, as well as customize your reading experience to show only the categories most relevant to you.
Signing up only take a few minutes, so why not give it a try and see what you've been missing out on.
Opportunistic infection of individuals on immunosuppressive therapy are a major problem for patient outcome, despite current prophylactic strategies. While the ability to prevent infection with well-characterized pathogens has improved, infection by less-known microbes have been on the rise. One such example is the increasing occurrence of mucormycosis, a life-threatening infection caused by Mucorales fungi. A defining characteristic of Mucorales is the ability to invade host cells via interaction with glucose-regulated protein 78 (GRP78) on the surface of endothelial cell.
In this issue of the Journal of Clinical Investigation, Ashraf Ibrahim and colleagues at the University of California, Los Angeles identified spore coat protein homologues (CotH) on the surface of Mucorales fungi as the ligand for GRP78 and that gene encoding these proteins are unique to Mucorales. Furthermore, loss of CotH in the Mucorales fungi Rhizopus oryzae decreased invasion and virulence.
In a companion commentary, J. Andrew Alspaugh of Duke University discusses the potential of targeting CotH proteins for prevention and treatment of mucormycosis.
ACCOMPANYING COMMENTARY TITLE: Hostile takeover: fungal protein promotes host cell invasion
Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our Infectious Diseases / Bacteria / Viruses category page for the latest news on this subject.
Please use one of the following formats to cite this article in your essay, paper or report:
Journal of Clinical Investigation. "Fungal surface protein promotes host cell." Medical News Today. MediLexicon, Intl., 31 Dec. 2013. Web.
7 Mar. 2014. <http://www.medicalnewstoday.com/releases/270559>
Journal of Clinical Investigation. (2013, December 31). "Fungal surface protein promotes host cell." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
If you write about specific medications, operations, or procedures please do not name healthcare professionals by name.
For any corrections of factual information, or to contact our editorial team, please use our feedback form. Please send any medical news or health news press releases to:
Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.
This page was printed from: http://www.medicalnewstoday.com/releases/270559.php
Visit www.medicalnewstoday.com for medical news and health news headlines posted throughout the day, every day.
© 2004-2014 All rights reserved. MNT (logo) is the registered trade mark of MediLexicon International Limited.