Creating a free account will enable you to subscribe to our daily and weekly email newsletters, as well as customize your reading experience to show only the categories most relevant to you.
Signing up only take a few minutes, so why not give it a try and see what you've been missing out on.
The study presents the first description of a set of related nuceleotide sequences essential for the role of these small molecules in intercellular communication.
The role of microRNAs (miRNAs) is fundamental for the correct moment-to-moment adjustment in the expression of target genes. "Before this study, we already knew that these small molecules could be packaged into small vesicles and exported to the extracellular space, to be later captured by other cells and in this way play an important role in intercellular communication," explains CNIC researcher Carolina Villarroya, the first author on the study.
What was not known until now was the mechanism by which miRNAs are encapsulated and exported. And this is precisely what graduate researcher Villarroya and Dr. María Mittelbrunn - from Prof. Sánchez Madrid's group - have discovered, working closely with Dr. Fátima Sánchez Cabo of the Bioinformatics Unit and Dr. Jesús Vázquez of the Proteomics Unit.
The article describes how a specific group of miRNAs that are actively exported in nanovesicles from human T lymphocytes share specific nucleotide sequence patterns called EXOmotifs. When these EXOmotifs are mutated, export of these miRNAs is impeded; and when they are introduced into other miRNAs, export is facilitated. EXOmotifs provide the binding site for a protein called hnRNPA2B1, which is responsible for transporting miRNAs to the interior of nanovesicles.
hnRNPA2B1 is also implicated in the transport of the genomic RNA of viruses such as HIV to sites of exit to the cell exterior. This establishes a parallel between the secretion of vesicles loaded with RNA and the production of viruses that parasitize the cellular machinery to extend infection.
The discovery suggests a new route for packaging RNA molecules of interest into nanovesicles, which have enormous potential as vehicles for gene therapy, vaccines and antitumor treatments. These findings form the basis of a new patent by the researchers and their institutions the CNIC and the UAM.
Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our Biology / Biochemistry category page for the latest news on this subject.
Please use one of the following formats to cite this article in your essay, paper or report:
de Investigaciones Cardiovasculare, Centro Nacional. "New mechanism that permits selective capture of microRNAs in nanovesicles that shuttle between cells." Medical News Today. MediLexicon, Intl., 31 Dec. 2013. Web.
20 Apr. 2014. <http://www.medicalnewstoday.com/releases/270565>
de Investigaciones Cardiovasculare, C. (2013, December 31). "New mechanism that permits selective capture of microRNAs in nanovesicles that shuttle between cells." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
If you write about specific medications, operations, or procedures please do not name healthcare professionals by name.
For any corrections of factual information, or to contact our editorial team, please use our feedback form. Please send any medical news or health news press releases to:
Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.
This page was printed from: http://www.medicalnewstoday.com/releases/270565.php
Visit www.medicalnewstoday.com for medical news and health news headlines posted throughout the day, every day.
© 2004-2014 All rights reserved. MNT is the registered trade mark of MediLexicon International Limited.