PLGA tubes are superior to autologous nerve graft for repaired sciatic nerve
The viscoelasticity of natural and artificial biomaterials can be suitable for human physiological function by matching stress relaxation and creep properties.
Dr. Chengdong Piao and colleagues from Second Hospital, Jilin University in China prepared sciatic nerve injury models by creating a 10 mm defect in sciatic nerve specimens harvested from fresh corpses, and defects were repaired by anastomosis with nerve autografts and poly(lactic-co-glycolic acid) (PLGA) tubes. They found that stress relaxation and creep testing showed that at 7 200 seconds, the sciatic nerve anastomosed by PLAG tubes exhibited a greater decrease in stress and increase in strain than those anastomosed by nerve autografts, suggesting that PLGA exhibits good viscoelasticity to meet the biomechanical requirements for a biomaterial used to repair sciatic nerve injury.
Their study was published in the Neural Regeneration Research (Vol. 8, No. 33, 2013).
Viscoelasticity of repaired sciatic nerve by poly(lactic-co-glycolic acid) tubes, Piao CD, Li P, Liu GY, Yang K, Neural Regen Res. 2013;8(33):3131-3138.
Image credit: Neural Regeneration Research