Creating a free account will enable you to subscribe to our daily and weekly email newsletters, as well as customize your reading experience to show only the categories most relevant to you.
Signing up only take a few minutes, so why not give it a try and see what you've been missing out on.
Corneal blindness affects more than 5 million individuals, many of whom suffer from diabetes
Investigators at the Cedars-Sinai Regenerative Medicine Institute have identified new molecular abnormalities in the diabetic cornea that could contribute to eye problems in affected patients. With this new knowledge, investigators aim to accelerate the process of healing and repair in damaged corneas to ultimately reverse the effects of diabetes-induced eye complications.
"We observed small but significant changes in the gene expressions between normal and diabetic corneas," said Mehrnoosh Saghizadeh Ghiam, PhD, assistant professor of biomedical sciences and neurosurgery, a researcher in the Regenerative Medicine Institute Eye Program and the lead author of the study published in the journal PLOS ONE. "These slight alterations may contribute to disease progression and cause cascading effects on the cellular functions that prevent wound healing and eventually contribute to vision impairment."
Diabetes is a systemic disease affecting all parts of the body, including the eye and may lead to vision loss. Roughly 50 to 70 percent of diabetic patients suffer from corneal complications that include alterations in vital corneal stem cells, causing lasting defects and eventually, vision impairment.
Investigators identified gene expression regulators, microRNAs, in normal and diabetic human corneas. They then successfully confirmed that several of these regulators were expressed differently in the diabetic corneas. These differently expressed microRNAs may contribute to stem cell and epithelial (tissue cells) abnormalities in diabetic corneas. Researchers are working on the manipulation of these microRNAs by gene therapy to normalize these corneas.
"No previous studies have addressed the role of microRNAs in the corneas of patients with diabetes," said Alexander Ljubimov, PhD, director of the Eye Program at the Regenerative Medicine Institute and co-author of the paper. "This first-of-a-kind study will allow researchers to better understand the roles of microRNAs in corneal diseases."
The study was conducted by a team of Cedars-Sinai researchers including Saghizadeh Ghiam, Ljubimov, Vincent Funari, PhD, director of the Cedars-Sinai Genomics Core in the Department of Biomedical Sciences, and research associates Michael Winkler and Jordan Brown.
The research was supported by the following National Institutes of Health (NIH) grants: NIH R21 EY022771 and R01 EY13431, as well as the Cedars-Sinai Regenerative Medicine Institute.
Citation: PLOS ONE. 2013 Dec 20.
Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our Eye Health / Blindness category page for the latest news on this subject.
Please use one of the following formats to cite this article in your essay, paper or report:
Center, Cedars-Sinai Medical. "Advancements in diabetes-induced blindness research." Medical News Today. MediLexicon, Intl., 17 Jan. 2014. Web.
9 Mar. 2014. <http://www.medicalnewstoday.com/releases/271301>
Center, C. (2014, January 17). "Advancements in diabetes-induced blindness research." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
If you write about specific medications, operations, or procedures please do not name healthcare professionals by name.
For any corrections of factual information, or to contact our editorial team, please use our feedback form. Please send any medical news or health news press releases to:
Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.
This page was printed from: http://www.medicalnewstoday.com/releases/271301.php
Visit www.medicalnewstoday.com for medical news and health news headlines posted throughout the day, every day.
© 2004-2014 All rights reserved. MNT (logo) is the registered trade mark of MediLexicon International Limited.