Creating a free account will enable you to subscribe to our daily and weekly email newsletters, as well as customize your reading experience to show only the categories most relevant to you.
Signing up only take a few minutes, so why not give it a try and see what you've been missing out on.
Celiac disease patients who experience chronic damage in the small intestine may be more likely to break a hip than those whose intestinal tissues have begun healing, according to new research accepted for publication in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).
Celiac disease is an autoimmune condition that affects about 1 percent of the U.S. population. When people with the condition eat gluten - a protein found in grains like wheat - it triggers an immune response in the small intestine. Patients with this condition face a higher risk of breaking a bone, but studies have reached contradictory conclusions about whether the fracture risk remains elevated long after the disease is diagnosed and managed with a gluten-free diet.
"We believe that giving the mucous membrane - the moist tissue lining the small intestine - a chance to heal can lower the risk of complications, including bone fractures, in celiac patients," said one of the study's authors, Jonas F. Ludvigsson, PhD, MD, of Karolinska University Hospital and Karolinska Institute in Stockholm, Sweden. "Our research confirmed that patients had a higher rate of hip fractures when tissue damage persisted over time. Sticking to a gluten-free diet is crucial for minimizing tissue damage and reducing the risk of a serious fracture that could cause other complications."
The cohort study analyzed tissue samples from 7,146 Swedes who were diagnosed with celiac disease from July 1969 to February 2008 and received follow-up biopsies within five years of diagnosis. Researchers examined intestinal tissue from the biopsies to determine the level of damage. Among this population, 43 percent had persistent villous atrophy where the intestinal tissue did not heal. (The villi are tiny structures that project from the lining of the small intestine.)
Researchers analyzed patient records to determine how many had broken bones. Patients were monitored for a median of 10.3 years after being diagnosed with celiac disease. The study found that people who had persistent tissue damage were more likely to break a hip. All patients faced a similar risk close to the time of the follow-up biopsy. The group with persistent tissue damage had a heightened risk of hip fracture beginning five years after the follow-up biopsy, indicating a higher long-term risk.
"Physicians have debated whether people with celiac disease actually benefit from a follow-up biopsy to determine the level of tissue healing taking place," said one of the study's authors, Benjamin Lebwohl, MD, MS, of the Celiac Disease Center at Columbia University Medical Center in New York. "These findings suggest that a follow-up biopsy can be useful for predicting complications down the road."
Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our Food Intolerance category page for the latest news on this subject.
Please use one of the following formats to cite this article in your essay, paper or report:
Society, The Endocrine. "Celiac disease increases risk for hip-fracture." Medical News Today. MediLexicon, Intl., 20 Jan. 2014. Web.
10 Mar. 2014. <http://www.medicalnewstoday.com/releases/271355>
Society, T. (2014, January 20). "Celiac disease increases risk for hip-fracture." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
If you write about specific medications, operations, or procedures please do not name healthcare professionals by name.
For any corrections of factual information, or to contact our editorial team, please use our feedback form. Please send any medical news or health news press releases to:
Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.
This page was printed from: http://www.medicalnewstoday.com/releases/271355.php
Visit www.medicalnewstoday.com for medical news and health news headlines posted throughout the day, every day.
© 2004-2014 All rights reserved. MNT (logo) is the registered trade mark of MediLexicon International Limited.