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Monoclonal antibodies directed against tumor antigens have proven effective for treating some forms of cancer. Despite the increasing use of monoclonal antibody therapy, it is not clear how these antibodies drive tumor removal.
In this issue of the Journal of Clinical Investigation, Marjolein van Egmond and colleagues at the VU University Medical Center found that macrophage populations mediate tumor cell removal following monoclonal antibody treatment by actively phagocytosing tumor cells. Macrophage-dependent tumor cell removal required both the high affinity and low affinity Fc receptors.
This study suggests that monoclonal antibody therapies that are optimized to enhance macrophage recruitment and activity may enhance removal of circulating tumor cells in cancer patients.
Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our Cancer / Oncology category page for the latest news on this subject.
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Journal of Clinical Investigation. "Monoclonal antibody therapy enhances removal of circulating tumor cells." Medical News Today. MediLexicon, Intl., 20 Jan. 2014. Web.
10 Mar. 2014. <http://www.medicalnewstoday.com/releases/271362>
Journal of Clinical Investigation. (2014, January 20). "Monoclonal antibody therapy enhances removal of circulating tumor cells." Medical News Today. Retrieved from
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