Creating a free account will enable you to subscribe to our daily and weekly email newsletters, as well as customize your reading experience to show only the categories most relevant to you.
Signing up only take a few minutes, so why not give it a try and see what you've been missing out on.
A new study from Karolinska Institutet in Sweden finds that testing for human papilloma virus (HPV) allows for longer time between screening tests when compared to cytology-based testing. The study is published in the scientific journal British Medical Journal (BMJ).
Cervical screening programs have until recently relied on cytology to identify women at risk for developing cervical cancer. However, it has long been known that testing screening with human papillomavirus (HPV) DNA tests has a higher sensitivity for cervical intraepithelial neoplasia (CIN), the lesion that the program intends to find since it can progress to cervical cancer if left untreated. Until now, it has been unclear whether HPV-based screening results in overdiagnosis of lesions that would not have progressed to cancer. Also, it has not been clear whether, if implemented, the screening interval could be prolonged when using HPV-based screening.
The current study is a long-term follow-up of the national randomized controlled trial Swedescreen. The trial was started in1997 and enrolled more than 12,000 women in ages 32-38 from all over Sweden. The women were randomized to either double testing with both HPV testing and cytology, or only cytology test. At the follow-up 13 years after the start of the study, the researchers found that the increased detection rate for pre-cancerous lesions of HPV-based screening reflects earlier detection rather than over-diagnosis. The researchers also investigated the duration of the protective effect of the two screening methods by over time comparing the incidence of pre-cancerous lesions in women who had negative test results in the screening.
"The protection of HPV-based screening after five years is about the same as for cytology-based screening after three years", says Miriam Elfström at the Department of Medical Epidemiology and Biostatistics, first author of the study. "This indicates that 5-year screening intervals could be used with HPV-based screening, instead of the current 3-year intervals".
Long term duration of protective effect for HPV negative women: follow-up of primary HPV screening randomised controlled trial, K Miriam Elfström, Vitaly Smelov, Anna L V Johansson, Carina Eklund, Pontus Nauclér, Lisen Arnheim-Dahlström, Joakim Dillner, BMJ (2014) - doi.org/10.1136/bmj.g130
Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our Cervical Cancer / HPV Vaccine category page for the latest news on this subject.
Please use one of the following formats to cite this article in your essay, paper or report:
Institutet, Karolinska. "Longer screening intervals possible with HPV-based tests." Medical News Today. MediLexicon, Intl., 22 Jan. 2014. Web.
16 Apr. 2014. <http://www.medicalnewstoday.com/releases/271493>
Institutet, K. (2014, January 22). "Longer screening intervals possible with HPV-based tests." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
If you write about specific medications, operations, or procedures please do not name healthcare professionals by name.
For any corrections of factual information, or to contact our editorial team, please use our feedback form. Please send any medical news or health news press releases to:
Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.
This page was printed from: http://www.medicalnewstoday.com/releases/271493.php
Visit www.medicalnewstoday.com for medical news and health news headlines posted throughout the day, every day.
© 2004-2014 All rights reserved. MNT (logo) is the registered trade mark of MediLexicon International Limited.