Creating a free account will enable you to subscribe to our daily and weekly email newsletters, as well as customize your reading experience to show only the categories most relevant to you.
Signing up only take a few minutes, so why not give it a try and see what you've been missing out on.
Dihydroartemisinin-piperaquine is more effective than artemether-lumefantrine, and has fewer side effects than artesunate-mefloquine' concludes a systematic review published by the Cochrane Infectious Disease Group, hosted by LSTM.
Dihydroartemisinin-piperaquine is one of five artemisinin-based combination therapies currently recommended by the World Health Organization (WHO), and this review finds that it is also one of the most studied. The team of authors from South Africa, Kenya, Geneva and Liverpool included 27 randomized studies, enrolling 16,382 adults and children, which directly compared the relative efficacy and safety of dihydroartemisinin-piperaquine and the widely used alternatives; artemether-lumefantrine, artesunate plus mefloquine, and artesunate plus amodiaquine.
"The very long duration of action of piperaquine in this combination, means that DHA-P reduces the risk of the person suffering another bout of malaria for up to nine weeks after treatment", explained David Sinclair from LSTM.. "This gives it an advantage over most of the other combinations. Mefloquine has a similarly long duration of action but commonly causes side-effects such as nausea, vomiting and dizziness."
Dihydroartemisinin-piperaquine also became one of the few antimalarials to be formally registered by a stringent regulatory authority when the European Medicines Agency approved it for use in 2013. The registration process highlighted concerns that dihydroartemisinin-piperaquine caused some short term changes in electrocardiographs tracing the conduction of the heart rhythm. The review also examined this effect, and the authors report that the number of people affected by these changes is small and all resolved spontaneously without serious consequences.
Dihydroartemisinin-piperaquine for treating uncomplicated Plasmodium falciparum malaria, Babalwa Zani, Michael Gathu, Sarah Donegan, Piero L Olliaro, David Sinclair, The Cochrane Library - DOI: 10.1002/14651858.CD010927
Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our Tropical Diseases category page for the latest news on this subject.
Please use one of the following formats to cite this article in your essay, paper or report:
Liverpool School of Tropical Medicine. "Dihydroartemisinin-piperaquine for treating uncomplicated Plasmodium falciparum malaria." Medical News Today. MediLexicon, Intl., 22 Jan. 2014. Web.
8 Mar. 2014. <http://www.medicalnewstoday.com/releases/271504>
Liverpool School of Tropical Medicine. (2014, January 22). "Dihydroartemisinin-piperaquine for treating uncomplicated Plasmodium falciparum malaria." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
If you write about specific medications, operations, or procedures please do not name healthcare professionals by name.
For any corrections of factual information, or to contact our editorial team, please use our feedback form. Please send any medical news or health news press releases to:
Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.
This page was printed from: http://www.medicalnewstoday.com/releases/271504.php
Visit www.medicalnewstoday.com for medical news and health news headlines posted throughout the day, every day.
© 2004-2014 All rights reserved. MNT (logo) is the registered trade mark of MediLexicon International Limited.