Creating a free account will enable you to subscribe to our daily and weekly email newsletters, as well as customize your reading experience to show only the categories most relevant to you.
Signing up only take a few minutes, so why not give it a try and see what you've been missing out on.
With plummeting hormone levels, natural menopause before age 40 can put a damper on women's mental well being and quality of life. But bringing testosterone back up to normal may not bring them the boost some hoped for, found a new study published online in Menopause, the journal of The North American Menopause Society (NAMS).
Before age 40, ovaries stop functioning in about 1% of women without some obvious genetic abnormality to blame, bringing on an early menopause. Called "primary ovarian insufficiency" or POI, the condition can spell not only infertility and other physical problems but also depression and decreased quality of life. Adding back lost estrogen and progesterone helps. But ovaries normally produce testosterone, too, which has mental and physical effects. Adding it back, some thought, could be helpful.
But studies looking at adding testosterone for women who lose ovarian function for other reasons, such as after natural menopause or hysterectomy, haven't yielded consistent results. So these investigators looked at the mood and quality of life data from women with POI in a study done at the National Institutes of Health Clinical Center in Bethesda, MD, where women underwent a year of hormone therapy that included testosterone. In the randomized, double-blind, placebo controlled study, 61 women used placebo patches and 67 women used patches that delivered 150 micrograms of testosterone a day, similar to the Intrinsa patch that was rejected by FDA as a treatment for low sexual desire in women.
After 12 months, testosterone levels were back up to normal for the women who got the treatment. The investigators saw no detrimental effects of testosterone, but they found no significant improvement either in measurements of quality of life, self esteem and mood compared with placebo.
Bringing testosterone back to normal doesn't help these aspects of life, suggesting that it's something other than testosterone that plays a role in mood problems for women with POI, concluded the researchers.
But there are still unknowns. The study didn't measure depression and sexual function specifically, so the investigators couldn't draw conclusions about the effects of normalizing testosterone on those problems. Having some effect on desire may take raising testosterone to higher-than-normal levels, according to some studies, although that poses questions about safety.
"This study makes an important contribution toward understanding what testosterone can and cannot do. With all the hype about testosterone and aging, it is important that the public have the facts," says NAMS Executive Director Margery Gass, MD.
The article, "Effects of physiologic testosterone therapy on quality of life, self-esteem and mood in women with primary ovarian insufficiency," will be published in the September print edition of Menopause.
Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our Menopause category page for the latest news on this subject.
Please use one of the following formats to cite this article in your essay, paper or report:
The North American Menopause Society (NAMS). "Bringing testosterone back up to normal for women going through early menopause has disappointing results." Medical News Today. MediLexicon, Intl., 31 Jan. 2014. Web.
19 Apr. 2014. <http://www.medicalnewstoday.com/releases/271950>
The North American Menopause Society (NAMS). (2014, January 31). "Bringing testosterone back up to normal for women going through early menopause has disappointing results." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
If you write about specific medications, operations, or procedures please do not name healthcare professionals by name.
For any corrections of factual information, or to contact our editorial team, please use our feedback form. Please send any medical news or health news press releases to:
Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.
This page was printed from: http://www.medicalnewstoday.com/releases/271950.php
Visit www.medicalnewstoday.com for medical news and health news headlines posted throughout the day, every day.
© 2004-2014 All rights reserved. MNT is the registered trade mark of MediLexicon International Limited.