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Lysosomal storage disorders (LSDs) are a common cause of neurodegenerative disease in young children.
These diseases are difficult to diagnosis in the early stages; therefore, it is difficult to develop therapeutic strategies that prevent symptom onset.
In this issue of the Journal of Clinical Investigation, Frances M. Platt and colleagues at the University of Oxford devised a method for evaluating the relative volume of acidic compartments as an indicator of LSDs.
Using the commercially available pH-indicator dye, Lysotracker, the authors were able to calculate the relative acidic compartment volume in circulating B cells. Use of this metric in samples from young LSD patients revealed that the relative acidic compartment volume correlated with clinical severity, and could be used to evaluate patient response to a particular therapy.
Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
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Journal of Clinical Investigation. "Researchers characterize a biomarker for lysosomal storage disorders." Medical News Today. MediLexicon, Intl., 5 Feb. 2014. Web.
23 Apr. 2014. <http://www.medicalnewstoday.com/releases/272124>
Journal of Clinical Investigation. (2014, February 5). "Researchers characterize a biomarker for lysosomal storage disorders." Medical News Today. Retrieved from
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