Creating a free account will enable you to subscribe to our daily and weekly email newsletters, as well as customize your reading experience to show only the categories most relevant to you.
Signing up only take a few minutes, so why not give it a try and see what you've been missing out on.
T-cells, the elite guard of the immune system in humans and other mammals, ignore normal biologic protocol and swing into high gear when attacked by certain fast-moving bacteria, reports a team of researchers led by a UC Davis immunologist.
The description of this previously undefined immune pathway provides information vital for designing vaccines and medicines to prevent or treat deadly infectious diseases caused by bacteria such as Salmonella and Chlamydia. The results from this recent mouse-based study were reported online in the journal Immunity.
"Our study shows that the body's immune system functions very differently when it faces a rapidly growing pathogen like Salmonella or Chlamydia," said immunologist Stephen McSorley, an associate professor at UC Davis' Center for Comparative Medicine, which investigates diseases that afflict both humans and animals.
"The strict rules that normally govern T-cell activation are relaxed so that the host animal has the best possible chance of a maximal response and ultimately staying alive," he said.
T-cells, which belong to a group of white blood cells called lymphocytes, normally respond defensively to the presence of substances known as antigens, which are produced by invading bacteria and viruses. It's widely known that T-cells launch an immune defense when they recognize specific antigens.
However in this study, the researchers demonstrated in the mouse that certain T-cells don't require the presence of specific antigens to launch an effective immune response. During fast-moving Salmonella and Chlamydia infections, a cascade of other antimicrobial interactions occur that trigger these T-cells to respond defensively to the bacterial attacks, even without the presence of specific antigens.
The researchers also showed that when this defensive pathway was disrupted during Salmonella infection, the mice had greater difficulty getting rid of the bacterial disease.
The researchers note that further study is needed to determine if this newly defined antimicrobial pathway also can provide protection against co-infections by multiple disease-causing microbes.
Other researchers on the study were Hope O'Donnell, Oanh H. Pham, Lin-xi Li, Shaikh M. Atif, Seung-Joo Lee, Marietta M. Ravesloot, Jessica L. Stolfi, Sean-Paul Nuccio and Andreas J. Baumler, all of UC Davis; and Petr Broz and Denise M. Monack, both of Stanford University.
The National Institutes of Health and the Vietnam Education Foundation provided funding for the study.
Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our Infectious Diseases / Bacteria / Viruses category page for the latest news on this subject.
Please use one of the following formats to cite this article in your essay, paper or report:
University of California - Davis. "New study defines powerful bacterial immune response." Medical News Today. MediLexicon, Intl., 9 Feb. 2014. Web.
19 Apr. 2014. <http://www.medicalnewstoday.com/releases/272332>
University of California - Davis. (2014, February 9). "New study defines powerful bacterial immune response." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
If you write about specific medications, operations, or procedures please do not name healthcare professionals by name.
For any corrections of factual information, or to contact our editorial team, please use our feedback form. Please send any medical news or health news press releases to:
Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.
This page was printed from: http://www.medicalnewstoday.com/releases/272332.php
Visit www.medicalnewstoday.com for medical news and health news headlines posted throughout the day, every day.
© 2004-2014 All rights reserved. MNT is the registered trade mark of MediLexicon International Limited.