Hippocampal neuronal apoptosis due to cerebral infarction prevented by pretreatment with SSTF
Focal cerebral ischemia-reperfusion may lead to neuronal loss in the hippocampus, which is regarded as one of the basic pathological mechanisms underlying cognitive impairment.
The neuronal apoptosis plays an important role in cerebral infarction, determining the number of loss of neurons and infarct volume.
Growing evidence has suggested that Chinese herbs can inhibit hippocampal apoptosis caused by ischemia-reperfusion.
Prof. Shumin Zhao and team from Chengde Medical College in China pretreated rats with scutellaria baicalensis stem-leaf total flavonoid (SSTF) intragastrically for 7 days before focal cerebral ischemia-reperfusion injury models were established using the suture method.
The researchers found that scutellaria baicalensis stem-leaf total flavonoids reduced the infarct volume and apoptosis in hippocampal neurons, restored neurological deficits, and improved the integrity of the blood-brain barrier in rats with cerebral ischemia-reperfusion injury.
Meanwhile, SSTF increased the expression of the anti-apoptotic protein Bcl-2 and decreased the expression of the pro-apoptotic protein Bax, but could not prevent apoptosis.
These findings, published in Neural Regeneration Research (Vol. 8, No. 34, 2013), suggest that SSTF may act on multiple areas and pathways to protect rat hippocampal tissue from ischemia-reperfusion injury, and thus may be useful for the clinical prevention and treatment of ischemic brain injury.