Consider HCT 1026 for very young autistic infants and toddlers, letter to Medical News Today

Main Category: Autism
Article Date: 28 Jul 2005 - 0:00 PDT

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Letter -

Consider HCT 1026 (a nitric-oxide donating derivative of flurbiprofen) for treatment of very young autistic infants and toddlers, in combination with intensive educational intervention (the latter of which has shown scientifically to help autistic children function better).

I base this recommendation on the work of Lennart Gustafsson Ph.D. who has suggested that inadequate expression of Nitric Oxide in critical points of brain development are predicted to lead to narrow cortical minicolumns (shown to occur in autistics on autopsy data per the work of Manny Casanova M.D.).

How safe is HCT 1026 in young children? What are the potential side effects? A researcher who might be interested in this is Mirjana Maletic-Savatic M.D., Ph.D.

She is a pediatric neurologist and researcher interested in autism, and has studied neuronal Nitric Oxide Synthase knock-out mice relative to this. She is at the University at Stonybrook in New York in Pediatric Neurology.

Dr. Gustafsson's email address is: Lennart.Gustafsson@sm.luth.se. Another researcher interested in nitric oxide and brain development is Grigori Enikolopov Ph.D. at Cold Spring Harbor Lab in New York. his email address is enik@cshl.edu.

Thanks,

Linda Copeland M.D.
lecopeland@ucdavis.edu
http://www.ucdavis.edu

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