Thoughts on thyroid biology

Main Category: Endocrinology
Article Date: 27 Aug 2005 - 6:00 PDT

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In a study appearing online on August 25 in advance of print publication of the September 1 issue of the Journal of Clinical Investigation, Ana Luiza Maia and colleagues from Harvard have developed a novel system to address a long- standing question in thyroid biology - the relative contribution of Type 1 (D1) and Type 2 (D2) 5'-deiodinase to circulating T3 in humans. They show that D2 accounts for a higher fraction of T3 production in hypothyroidism and D1 in hyperthyroidism. D2 generated T3 is shown to have a greater effect on T3-dependent gene expression.

TITLE:Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans.

AUTHOR:
Ana Luiza Maia
Harvard Medical School, Boston, MA USA
View the PDF of this article at:
the-jci.org/article.php?id=25083

Stacie Bloom
press_releases@the-jci.org
212-342-4159
Journal of Clinical Investigation
http://www.jci.org

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