Parkinson's and One of Its Substrates

Main Category: Parkinson's Disease
Article Date: 01 Sep 2005 - 1:00 PDT

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One of the familial forms of Parkinson's disease (PD), autosomal recessive juvenile parkinsonism (AR-JP), arises from a mutation in parkin, a ubiquitin ligase that normally targets proteins for degradation. This week, Ko et al. make a case that accumulation of a parkin substrate could be important in the pathogenesis of PD.

News tips from The Journal of Neuroscience

p38 Han Seok Ko, Rainer von Coelln, Sathya R. Sriram, Seong Who Kim, Kenny K. K. Chung, Olga Pletnikova, Juan Troncoso, Brett Johnson, Roya Saffary, Eyleen L. Goh, Hongjun Song, Bum-Joon Park, Min Jung Kim, Sunghoon Kim, Valina L. Dawson, and Ted M. Dawson

Sara Harris
sharris@sfn.org
202-462-6688
Society for Neuroscience
http://www.sfn.org

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Parkinson's Disease

What is Parkinson's Disease?

Parkinson's disease is a gradually progressive, degenerative neurologic disorder which typically impairs the patient's motor skills, speech, writing, as well as some other functions. Read more...

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