At the 45th Annual Meeting & Exhibition of the American Association for Dental Research, researcher Robert Schroth, University of Manitoba, Children's Hospital Research Institute of Manitoba, Winnipeg, Canada, presented a study titled "Microbiome Associated With Severe Caries in Canadian First Nations Children." The AADR Annual Meeting was held in conjunction with the 40th Annual Meeting of the Canadian Association for Dental Research.
To determine the caries-associated microbiome among Canadian First Nations children with severe early childhood caries (S-ECC). Canadian First Nations children
Data analysis included descriptive and bivariate analyses (Chi Square and t tests). A p value - 0.05 was significant. Thirty children with S-ECC and 20 caries-free controls participated. The mean age was 40.7±11.7 months and 56% were male. There were no significant differences between the groups with respect to sex or age (p=0.20 and p=0.11, respectively). Children with S-ECC were weaned from the bottle at a later age than those caries-free (25.8±12.0 months vs. 17.9±8.9, p=0.28). There was no difference in daily snacking frequency between the groups (p=0.71). Microbiome analyses revealed no new unique pathogens. However, the abundance of S. mutans rDNA relative to total bacterial rDNA was significantly higher in children with S-ECC (5.99%±7.01% vs. 0.21%±0.28%, p
There was an increased abundance of S. mutans, as well as population shifts in oral microbial communities in children with S-ECC. Canadian First Nations children with S-ECC had significantly higher levels of cariogenic microorganisms than their caries-free counterparts, which might explain the high prevalence of S-ECC in Indigenous children.