A long non-coding RNA, Morrbid, controls how long circulating myeloid cells live, which is key to maintaining the proper balance between fighting infection and exacerbating inflammation.

The discovery offers a potential therapeutic target for certain inflammatory disorders, such as asthma, Churg-Strauss syndrome and hypereosinophilic syndrome, that are characterized by abnormal myeloid cell lifespan.

Circulating myeloid cells (neutrophils, eosinophils and so-called "classical" monocytes) are the first line of defense against pathogens. Though these are among the shortest-lived cells in the body, dangerous levels of inflammation can result if they live too long and grow too numerous, but the mechanisms controlling lifespan in these cells were unknown.

Investigators including Adam Williams of The Jackson Laboratory, Richard Flavell of Yale University and Jorge Henao-Mejia of the University of Pennsylvania's Perelman School of Medicine looked to long non-coding RNAs (lncRNAs), key controllers of epigenetically regulated gene expression.

They discovered a novel lncRNA that tightly controls the survival of circulating myeloid cells and named it, appropriately, Morrbid (Myeloid RNA Regulator of Bim Induced Death). This lncRNA is conserved across species, including mouse and human, and is specific to neutrophils, eosinophils and monocytes.

Morrbid regulates lifespan by controlling the expression of Bim, a nearby gene that in turn controls apoptosis or programmed cell death in response to pro-survival cytokines. In other words, Morrbid overrides a signaling mechanism that prevents premature immune cell death.

Deleting Morrbid in mice led to a drastic reduction of myeloid cells that normally express thislncRNA, though other lymphoid and myeloid cell types (such as mast cells) were not affected. The mice had less ability to fight infection but gained protection against inflammation and immunopathology.

The human version of the gene, MORRBID, is dysregulated in patients with hypereosinophilic syndrome. The researchers note that this may represent a potential therapeutic target for inflammatory disorders that are characterized by aberrant short-lived myeloid cell lifespan.

The Jackson Laboratory is an independent, nonprofit biomedical research institution based in Bar Harbor, Maine, with a National Cancer Institute-designated Cancer Center, a facility in Sacramento, Calif., and a genomic medicine institute in Farmington, Conn. It employs 1,800 staff, and its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health.

Article: The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan, Kotzin et al., Nature, doi: 10.1038/nature18945, published online 15 August 2016.