Gastric bypass surgery is one of the most successful treatments for obesity and related disorders; however, some patients may not want to undergo surgery. In an attempt to reduce nutrient absorption and replicate the effects of gastric bypass surgery, researchers screened for inhibitors of an amino acid transporter, called B0AT1, and discovered a number of agents-including benztropine, a drug that is already in clinical use-as promising candidates.

"These compounds are just a start and need to be developed further, but they could potentially replace surgical procedures and be used together with other drugs to treat type 2 diabetes," said Dr. Stefan Bröer, senior author of the British Journal of Pharmacology study.

Article: Identification of novel inhibitors of the amino acid transporter B0AT1 (SLC6A19), a potential target to induce protein restriction and to treat type 2 diabetes, Qi Cheng, Nishank Shah, Angelika Bröer, Stephen Fairweather, Yang Jiang, Dieter Schmoll, Ben Corry, Stefan Bröer, British Journal of Pharmacology, doi: 10.1111/bph.13711, published online 8 February 2017.