Critical Role Of Gap Junction Coupled KATP Channel Activity For Regulated Insulin Secretion

Main Category: Diabetes
Article Date: 17 Jan 2006 - 13:00 PDT

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Gap junctions electrically couple pancreatic {lower case beta}- cells, and can preserve excitability (glucose sensitivity and insulin secretion) in the islet even when a majority of cells have nonfunctional ATP-activated potassium channels.

Citation: Rocheleau JV, Remedi MS, Granada B, Head WS, Koster JC, et al. (2006) Critical role of gap junction coupled KATP channel activity for regulated insulin secretion. PLoS Biol 4(2): e26.

LINK TO THE PUBLISHED ARTICLE:
dx.doi.org/10.1371/journal.pbio.0040026

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