Neural Transplants Provide Persistent Benefit In Patients With Huntington's Disease

Main Category: Huntingtons Disease
Also Included In: Neurology / Neuroscience;  Transplants / Organ Donations
Article Date: 28 Feb 2006 - 21:00 PDT

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Neuronal transplantation in Huntington's disease provides a period of improvement and stability of several years, according to an Article published online today (Monday February 27, 2006) by The Lancet Neurology.

Intracerebral cell therapy, which aims to substitute striatal neurons lost to Huntington's disease by striatal neuroblasts and neural precursors obtained from embryos after elective abortion, has proven beneficial in patients with the disease. Theoretical projection models suggest that the clinical effects of grafting will lead to an initial improvement followed by a period of secondary decline due to the ongoing disease process. However, follow-up has not been long enough to assess the duration of clinical benefit of the treatment up to now.

Anne-Catherine Bachoud-Lévi (Henri Mondor Hospital, France) and colleagues have previously shown, in a pilot study, that intracerebral neural grafts lead to motor and cognitive improvement in patients with Huntington's disease 2 years after the procedure. In their current article, they present data for five patients from their pilot study, assessed annually for up to 6 years after neural grafting.

The procedure provided long-term clinical benefits to three patients in parallel with long-lasting focal improvement in brain metabolic activity. Progression of the disease led to heterogeneous secondary clinical alterations and changes of cerebral metabolism.

Whereas neuronal transplantation is not a permanent cure for Huntington's disease, it does provide a period of improvement and stability. Although neuroprotective treatment seems to be unavoidable in the disease, improvement of the surgical procedure and in patient selection could improve the therapeutic value of neuronal transplantation. Bachoud-Lévi concludes: "Neuroprotection could stop the disease, but only a graft can restore lost function."

Anne-Catherine Bachoud-Lévi, INSERM U421 Equipe Avenir, Neuropsychologie interventionnelle, Faculté de Médecine, Paris, France.

Joe Santangelo
j.santangelo@elsevier.com
Lancet
http://www.thelancet.com

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