TPH2 Protein Involved In Development Of Depression And Manic Depression

Main Category: Depression
Also Included In: Psychology / Psychiatry;  Bipolar;  Neurology / Neuroscience
Article Date: 19 Mar 2006 - 0:00 PDT


About 1 in 10 Europeans has to contend with some form of depression during his or her life. But how people become depressed is still largely a mystery. With their recent research, scientists from the Flanders Interuniversity Institute for Biotechnology (VIB) connected to the University of Antwerp in collaboration with scientists of the University of Umeå in Sweden, are lifting a corner of the veil. Their studies indicate that the TPH2 protein is involved in the development of depression and manic depression.

Depression and manic depression

Depression is one of the most prevalent disorders in the Western world, and, according to the World Health Organization, it will even be the No. 1 disorder in 2020. Ten to 15 per cent of the population - from all levels of society - experience depression during their lifetime; and about 5% has to contend with manic depression. Despite the high socio-economic costs and mortality rate, the causes of these psychiatric disorders are not yet known. However, scientists are in agreement that the origin of depression can be attributed to a combination of hereditary and environmental factors such as stress.

The role of serotonin

The hormone serotonin plays an important role in our brain chemistry. The amount of serotonin in the brain has a large influence on our thinking, emotions and behavior. Because antidepressants affect the level of serotonin in the brain, it has long been suspected that serotonin plays a role in the development of psychiatric disorders. So, the amount of serotonin that you produce and keep under control appears to be crucial in the fight against (manic) depression. Because the TPH2 protein is instrumental in regulating the serotonin level, scientists suspect that TPH2 plays a role in the development of psychiatric disorders.

Genetic study

Ann Van Den Bogaert and her colleagues from the research group of Jurgen Del-Favero have also been studying the role of TPH2 in the development of depression and manic depression. They have conducted a genetic study in which they compared the variation in the TPH2 gene between patients with depression and healthy individuals. The DNA of two random individuals are 99.9% identical - the 0.1% that is different contains the genetic variation that can originate disorders.

In collaboration with the Swedish research group under the direction of Rolf Adolfsson and Karl-Fredrik Norrback, the researchers studied the DNA of hundreds of Swedish patients with depression and manic depression and that of healthy control subjects. By comparing the genetic variations between the patients and healthy individuals, they have shown that in this Swedish population TPH2 is involved in the development of depression and manic depression.

Thus, their research brings us a step closer to a better understanding of these psychiatric disorders.

The research was funded by IWT, FWO, VIB, IUAP and ALF Västerbottens Läns Landsting.

VIB, the Flanders Interuniversity Institute for Biotechnology, is a research institute where 850 scientists conduct gene technological research in a number of life-science domains, such as human health care and plant systems biology. Through a joint venture with four Flemish universities (Ghent University, the Catholic University of Leuven, the University of Antwerp, and the Free University of Brussels) and a solid funding program for strategic basic research, VIB unites the forces of nine university science departments in a single institute. Through its technology transfer activities, VIB strives to convert the research results into products for the benefit of consumers and patients. VIB also distributes scientifically substantiated information about all aspects of biotechnology to a broad public.

The Umeå Psychiatric Research Group of the University of Umeå in Sweden, has a long standing tradition of genetic studies. The 10 people working in this group perform research on psychiatric disorders and personality. They want to obtain a better understanding of these disorders in the hope that this can in the end lead to solutions for the patients.

Patients may refer questions to:
patienteninfo@vib.be

http://www.vib.be

• Additional
• References
• Citations