Cysteine Containing Chewing Gum Developed In Finland Is Hoped To Become A New Way For The Prevention Of Upper Digestive Tract Cancers
The research group of professor Mikko Salaspuro, University of Helsinki and Helsinki University Hospital, Finland, published already in 1990s a hypothesis, that microbes representing normal human digestive tract flora produce locally acetaldehyde from ethanol and that this may expose them for an increased risk of digestive tract cancers.
The hypothesis was strongly supported by Japanese studies showing that digestive tract cancer risk is markedly increased in Japanese drinkers, who have a decreased ability to remove acetaldehyde because of a gene mutation. The cause and effect relationship was subsequently strongly supported by a novel finding of the Finnish research group showing that after a small dose of alcohol Asians with the above mentioned gene mutation have 2-3 times higher concentrations of acetaldehyde in their saliva than those with the normal acetaldehyde removing enzyme. Most recently, a research group from NIH reported a mechanism that induces DNA-damage in those acetaldehyde concentrations that are found in the saliva after drinking of alcohol.
It has been known already for decades that a harmless aminoacid l-cysteine is able to bind effectively acetaldehyde and thereby eliminate its toxicity. On this basis professor Salaspuro and professor Martti Marvola, University of Helsinki, started to develop l-cysteine containing and acetaldehyde eliminating preparations that eventually could be used for the prevention of digestive tract cancers. The first two preparations were slowly l-cysteine releasing tablets that effectively eliminated acetaldehyde derived to the mouth and saliva either after a challenge of alcohol or during smoking.
The methods developed by the research groups of Salaspuro and Marvola have been patented world wide. The owner of the patents is nowadays Finnish company Biohit Oyj. The first commercial product based on this patented method is l-cysteine containing chewing gum that was launched on the market in the 11th International Congress of Oral Cancer on May 14-17, in Italy.
?We know that with this chewing gum it is possible to eliminate acetaldehyde totally from the saliva during smoking. We do hope that this will in the future turn out to be a novel method for the prevention of alcohol and tobacco smoking associated oral cancers. However, long term randomised controlled trials are naturally needed before the possible cancer preventive effects can be proved. We are currently planning that type of studies?, says Salaspuro.
With the saliva carcinogenic acetaldehyde is distributed after swallowing to the pharynx, oesophagus and stomach. Consequently, the effects of l-cysteine may extend to the whole upper digestive tract area. On the other hand, carcinogenic acetaldehyde can be produced also endogenously by the oral microbes from various foodstuffs with high sugar or carbohydrate content, especially in an achlorhydric stomach. Atrophic gastritis and achlorhydria are well known risk factors of gastric cancer. Therefore, in addition to the chewing gum, also other cysteine containing preparations are under development. The goal is to develop new products releasing slowly cysteine in different parts of the gastrointestinal tract by which acetaldehyde can be eliminated not only in the mouth but also in the stomach and may be also in the large intestine.
About the HELSINGIN YLIOPISTO (UNIVERSITY OF HELSINKI)
Founded in Turku in 1640, the University moved to Helsinki in 1828. The University of Helsinki has nine faculties: Theology, Law, Medicine, Arts, Science, Education, Social Sciences, Agriculture and Forestry, Veterinary Medicine.
HELSINGIN YLIOPISTO (UNIVERSITY OF HELSINKI)
P.O. Box 33
There are no references listed for this article.
Please use one of the following formats to cite this article in your essay, paper or report:
Smeer, Richard. "Cysteine Containing Chewing Gum Developed In Finland Is Hoped To Become A New Way For The Prevention Of Upper Digestive Tract Cancers." Medical News Today. MediLexicon, Intl., 23 May. 2006. Web.
25 Jun. 2017. <http://www.medicalnewstoday.com/releases/43867.php>
Smeer, R. (2006, May 23). "Cysteine Containing Chewing Gum Developed In Finland Is Hoped To Become A New Way For The Prevention Of Upper Digestive Tract Cancers." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
Contact our news editors
For any corrections of factual information, or to contact our editorial team, please see our contact page.
Copyright Medical News Today: Excluding email/sharing services explicitly offered on this website, material published on Medical News Today may not be reproduced, or distributed without the prior written permission of Medilexicon International Ltd. Please contact us for further details.