ADVENTRX To Present Two CoFactor Clinical Abstracts At Gastrointestinal Cancer Conference

Main Category: GastroIntestinal / Gastroenterology
Also Included In: Cancer / Oncology
Article Date: 21 Jun 2006 - 0:00 PDT

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ADVENTRX Pharmaceuticals, Inc. (Amex: ANX) announced today that it will present two CoFactor(R) clinical development abstracts at the 8th World Congress on Gastrointestinal Cancer. The conference takes place June 28-July 1, 2006 in Barcelona, Spain.

The following abstracts were accepted for presentation at the conference:

"Response to second line treatment following 5,10-methylenetetrahydrofolic acid (CoFactor) with 5-fluorouracil as first line treatment in metastatic colorectal cancer" (abstract number 620).

"Pharmacokinetics of 5,10-methylenetetrahydrofolate administered as a 2-hour infusion" (abstract number 623).

About CoFactor

CoFactor (ANX-510) is a folate-based biomodulator drug designed to enhance the activity and reduce associated toxicity of the widely used cancer chemotherapeutic agent 5-fluorouracil (5-FU). CoFactor creates more stable binding of the active form of 5-FU to the target enzyme, thymidylate synthase (TS), improving 5-FU performance. The Company reported Phase II results from an independent radiological assessment that found an objective response of 35% in first line treatment of metastatic colorectal cancer with CoFactor and 5-FU. The Company also reported median time to tumor progression (TTP) of 162 days, preliminary median overall survival of 459 days with no study drug-related grade 3 or grade 4 gastrointestinal or hematological toxicity. The Company has received clearance under a special protocol assessment (SPA) from the US Food and Drug Administration (FDA) to begin a CoFactor Phase III pivotal clinical trial for metastatic colorectal cancer, which is currently planned to begin patient dosing in Q2 2006.

About ADVENTRX

ADVENTRX Pharmaceuticals is a biopharmaceutical research and development company focused on introducing treatments for cancer and infectious disease that surpass the performance and safety of existing drugs, by addressing significant problems such as drug metabolism, toxicity, bioavailability and resistance. More information can be found on the Company's Web site at http://www.adventrx.com.

Forward Looking Statement

This press release contains forward-looking statements, within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995, regarding ADVENTRX. Such statements are made based on management's current expectations and beliefs. Actual results may vary from those currently anticipated based upon a number of factors, including uncertainties inherent in the drug development process, the timing and success of clinical trials, the validity of research results, and the receipt of necessary approvals from the FDA and other regulatory agencies. For a discussion of such risks and uncertainties, which could cause actual results to differ from those contained in the forward-looking statements regarding ADVENTRX, see the section titled "Risk Factors" in ADVENTRX's last annual report on Form 10-K and its Quarterly Reports on Form 10-Q, as well as other reports that ADVENTRX files from time to time with the Securities and Exchange Commission. All forward-looking statements regarding ADVENTRX are qualified in their entirety by this cautionary statement. ADVENTRX undertakes no obligation to release publicly any revisions to forward-looking statements to reflect events or circumstances which occur after the date hereof.

ADVENTRX Pharmaceuticals, Inc.
http://www.worldgicancer.com

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