Aspirin is most cost effective way to prevent heart disease

Main Category: Statins
Article Date: 28 Nov 2003 - 0:00 PST

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Contact: Emma Dickinson
edickinson@bmj.com
44-0-20-7383-6529
BMJ-British Medical Journal

Coronary heart disease prevention: insights from modelling incremental cost effectiveness BMJ Volume 327, pp 1264-67. Editorial: What do we gain from the sixth coronary heart disease drug? BMJ Volume 327, pp 1237-8 Aspirin and blood pressure lowering drugs can prevent heart disease at a fraction of the cost of cholesterol lowering drugs (statins) and clopidogrel (an anti-clotting drug), finds a study in this week's BMJ.

Estimates of cost and effectiveness were obtained for aspirin, antihypertensive drugs, statins and clopidogrel. Cost per coronary event was calculated for treatments individually and in combination for patients at various levels of risk.

The most cost effective preventive treatments were aspirin and antihypertensive drugs, whereas simvastatin and clopidogrel were the least cost effective.

For instance, cost per coronary event prevented in a patient at 10% risk over five years was £3,500 for aspirin, £12,500 for initial antihypertensives, £18,300 for intensive antihypertensives, £60,000 for clopidogrel, and £61,400 for simvastatin.

These results cast doubt on present policy, says the author. A more efficient prevention strategy would be to offer most men over 55 and most women over 65 aspirin than to give statins to a few high-risk patients.

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