Cincinnati Children's Researchers Publish Findings On Potential Target For Leukemia Treatment

Main Category: Lymphoma / Leukemia / Myeloma
Also Included In: Immune System / Vaccines;  Blood / Hematology;  Biology / Biochemistry
Article Date: 10 Oct 2006 - 0:00 PDT

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Cincinnati Children's Hospital Medical Center today announced the publication of pioneering research identifying the crucial role and novel mechanism of action of the protein RhoH GTPase in the development and activation of cells critical to the immune system. The findings, along with other studies, suggest that RhoH GTPase may provide a target for therapeutic intervention in some types of leukemia. The paper is due to appear in an upcoming edition of the journal Nature Immunology and was recently posted in the advance online publication section of the journal's website, (http://www.nature.com/ni/index.html).

The paper describes detailed genetic and biochemical studies undertaken by researchers in the Division of Experimental Hematology and the Division of Immunobiology. The investigators succeeded in identifying a crucial role for RhoH GTPase in the development of thymocytes and activation of T-lymphocytes, both key processes in immune cell development. In addition, the researchers uncovered a novel mechanism for regulating RhoH activity, which may have broad implications in improving researchers' understanding of the mechanism of action of the Rho GTPase protein family and provide a potential target for leukemia drug development.

"We continue to make important progress in deciphering the molecular processes involved in the development and maintenance of the immune and blood system and how disruption of key proteins may contribute to leukemia," said David A Williams, M.D., Director of Experimental Hematology, Cincinnati Children's. "Through a collaboration with Ohio State University Comprehensive Cancer Center, we are now focused on translating these findings into developing new ways to target the protein as a novel approach to treating hematological malignancy."

The development of mature white blood cells, including lymphocytes, is a highly complex process involving cell growth as well as specific genetic and biochemical steps. Disruption of this process is associated with diseases such as leukemia.

RhoH GTPase is specific to blood-forming cells. Experiments have shown that its alteration affects several key steps in the growth and development of white blood cells. Moreover, clinical samples have implicated RhoH GTPase as a factor in leukemia and lymphoma. Further work is ongoing to decipher the specific mechanism of regulation and the function of RhoH GTPase in the development of white blood cell populations.

About Cincinnati Children's

Cincinnati Children's is a 475-bed institution devoted to bringing the world the joy of healthier kids. Cincinnati Children's has an international reputation for clinical and scientific excellence and is nationally the second largest recipient of research funding from the National Institutes of Health among pediatric institutions. The Cincinnati Children's Research Foundation was founded in 1931 and has a strong heritage of scientific discovery including advances that have benefited children worldwide such as the Sabin oral polio vaccine, a rotavirus vaccine and the first practical heart-lung machine that made open heart surgery possible.

Cincinnati Children's Hospital Medical Center
Cincinnati Children's Hospital

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