Prevalence Of Pelvic Floor Dysfunction In Patients With Interstitial Cystitis
The authors speculate that neural pathways coordinating smooth and striated muscle activity of the pelvic organs may respond to ongoing long-term stimulation by negatively impacting the nonirritated pelvic organs. This may lead to neurogenic inflammation and sensitization through the release of neurotrophic factors. It has been proposed that a noxious stimulus may trigger the release of nerve growth factor and substance P in the periphery causing the mast cells in the bladder to release proinflammatory substances leading to neurogenic inflammation of the bladder wall. This can result in BPS symptoms or vulvar or vaginal pain. The pelvic floor dysfunction may lead to voiding difficulties and ultimately urinary urgency, frequency, and pelvic pain.
Peters and colleagues suggest that if one suspect's pelvic floor dysfunction myofascial release may be offered as a first line of treatment. If bladder symptoms fail to respond then medical or surgical therapies directed toward the bladder can be provided.
Peters KM, Carrico DJ, Kalinowski SE, Ibrahim IA, Diokno AC
Urology. 70(1):16-18, July 2007
Reported by UroToday.com Contributing Editor Philip M Hanno, M.D
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