ASCO GU 2008 - Cardiovascular Mortality Following Androgen Deprivation Therapy For Locally Advanced Prostate Cancer: Analysis Of ROG 85-31

Main Category: Prostate / Prostate Cancer
Also Included In: Cardiovascular / Cardiology;  Men's health;  Clinical Trials / Drug Trials
Article Date: 16 Feb 2008 - 1:00 PDT

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UroToday.com - Androgen-deprivation therapy (ADT) decreases PCSM, but may be associated with greater risk of incident coronary artery disease (CAD), myocardial infarction and diabetes. Data from RTOG 85-31, a large trial of radiotherapy with or without ADT was used for this analysis. 945 men were randomized, and 50% of men were over age 70. Median duration of ADT was 4.2 years, and 64% of the radiotherapy patients ultimately received ADT at a mean time interval of 3 years.

A total of 574 deaths occurred, and 117 were CV related. No ADT related increase in CV mortality was found. In multivariate analysis of CV mortality with and without censoring at time of salvage ADT, ADT was not associated with increased CV mortality in men with locally advanced CaP. This is consistent with 5 other reports that ADT and radiotherapy is not associated with increased CV mortality. A CaPSURE report in 2007 reported a 4% increased risk of CV death with ADT in patients who had radical prostatectomy. An ADT increase in non-cancer CV mortality may possibly occur, through other mechanisms, such as additive with diabetes.

Presented by J. A. Efstathiou at the American Society of Clinical Oncology (ASCO) - 2008 Genitourinary Cancers Symposium - A Multidisciplinary Approach - February 14-16, 2008 San Francisco, California, USA

Reported by UroToday.com Contributing Editor Christopher P. Evans, MD, FACS Professor & Chairman Department of Urology University of California, Davis, School of Medicine Sacramento, CA

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