Beyond The Abstract Combined Exposure To Anti Androgens Causes Markedly Increased Frequencies Of Hypospadias In The Rat

Main Category: Urology / Nephrology
Also Included In: Men's health;  Sexual Health / STDs
Article Date: 08 Mar 2008 - 0:00 PDT

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UroToday.com - The study is a part of a larger study on mixtures of anti-androgens in a rat model. We expose the pregnant rats to the endocrine disrupters to estimate the risk for developmental effects on the offspring. Two central references for Christiansen et al. 2008 are:

Hass, U., Scholze, M., Christiansen, S., Dalgaard, M., Vinggaard, A. M., Axelstad, M. et al. (2007) Combined Exposure to Anti-Androgens Exacerbates Disruption of Sexual Differentiation in the Rat. Environmental Health Perspectives 115: 122-128.

Metzdorff, S. B., Dalgaard, M., Christiansen, S., Axelstad, M., Hass, U., Kiersgaard, M. K. et al. (2007) Dysgenesis and histological changes of genitals and perturbations of gene expression in male rats after in utero exposure to antiandrogen mixtures. Toxicol Sci 98: 87-98.

This work was supported by the European Commission, and financially supported by the European Union as part of the EDEN-project Endocrine Disrupters: Exploring Novel Endpoints, Exposure, Low Dose and Mixture-Effects in Humans, Aquatic Wildlife and Laboratory Animal' (QLK4-CT-2002-00603), and by the Danish Research Council grant no. 2107-04-0006.

Written by Sofie Christiansen, MD as part of Beyond the Abstract on UroToday.com. This initiative offers a method of publishing for the professional urology community. Authors are given an opportunity to expand on the circumstances, limitations, etc., of their research by referencing the published abstract.

Link to original abstract

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