Copyright 2009 Medical News Today Latest Cleft Palate News From Medical News Today. http://www.medicalnewstoday.com/sections/cleft_palate/ admin@medicalnewstoday.com (MNT Admin) editors@medicalnewstoday.com (MNT Editors) en-us Sun, 25 Oct 2009 00:00:00 PST http://www.medicalnewstoday.com/articles/168563.php http://www.medicalnewstoday.com/articles/168563.php Craniofacial surgeons around the world are striving toward a critical goal: making high-quality cleft palate and craniofacial reconstructive surgical services available to children in developing countries. Cleft Palate Thu, 08 Oct 2009 02:00:00 PST http://www.medicalnewstoday.com/articles/166605.php http://www.medicalnewstoday.com/articles/166605.php Although about half of all birth defects involve the face and skull, scientists remain unclear about why most occur. To help families at risk for these conditions, what's needed is a comprehensive and systematic understanding of how the faces of healthy children develop and what goes awry to cause common malformations. With today's improved technologies, researchers can generate megabytes of information in a single experiment on hundreds of genes that are involved in the process. Cleft Palate Sun, 04 Oct 2009 00:00:00 PST http://www.medicalnewstoday.com/articles/166091.php http://www.medicalnewstoday.com/articles/166091.php Titan Pharmaceuticals, Inc (Pink Sheets:TTNP) announced that the National Institutes of Health (NIH) has awarded a Research and Research Infrastructure Grand Opportunities grant to the company through the American Reinvestment and Recovery Act of 2009 (ARRA). The two year grant for Probuphine clinical development is expected to provide approximately $7.6 million, with the first year award of approximately $ 5.6 million now made available to Titan by the NIH. Alcohol / Addiction / Illegal Drugs Thu, 24 Sep 2009 05:00:00 PST http://www.medicalnewstoday.com/articles/165095.php http://www.medicalnewstoday.com/articles/165095.php Exposure to tetrachloroethylene (also known as perchlorethylene, PCE) may cause congenital birth defects. A study of expectant women exposed to PCE in drinking water, published in BioMed Central's open access journal Environmental Health, found an increased risk of oral clefts and neural tube defects in their children. Pregnancy / Obstetrics Mon, 16 Mar 2009 04:00:00 PST http://www.medicalnewstoday.com/articles/142380.php http://www.medicalnewstoday.com/articles/142380.php pSivida Corp, a leading drug delivery company, reported the interim 12-month safety and efficacy results from the first human pharmacokinetic study (PK Study) of Iluvien™. The study is being conducted by the Company's licensing partner Alimera Sciences. Iluvien is an intravitreal insert being developed for the treatment of diabetic macular edema (DME). Diabetes Mon, 09 Mar 2009 01:00:00 PST http://www.medicalnewstoday.com/articles/141508.php http://www.medicalnewstoday.com/articles/141508.php Comparing 500,000 snippets of human DNA put scientists from the University of Bonn on the right track. A genetic variant on chromosome 8 occurs with significantly higher frequency in people with cleft lip and palate than in the control group. The results are to be published in the forthcoming issue of the journal Nature Genetics. Cleft lips and palates are among the most frequent innate abnormalities. One in about 700 babies in Central Europe are affected. Cleft Palate Wed, 04 Mar 2009 02:00:00 PST http://www.medicalnewstoday.com/articles/140971.php http://www.medicalnewstoday.com/articles/140971.php A new study by physician researchers from Hasbro Children's Hospital and Children's Hospital Boston has identified an increased prevalence in left-handedness in children with a congenital disorder known as hemifacial microsomia (HFM). The study was published in the March 2009 edition of the Journal of Craniofacial Surgery. Overall, ten percent of the population is left-handed. Cleft Palate Sat, 28 Feb 2009 01:00:00 PST http://www.medicalnewstoday.com/articles/140618.php http://www.medicalnewstoday.com/articles/140618.php A system of opposing genetic forces determines why mammals develop a single row of teeth, while sharks sport several, according to a study published today in the journal Science. When completely understood, the genetic program described in the study may help guide efforts to re-grow missing teeth and prevent cleft palate, one of the most common birth defects. Dentistry Wed, 04 Feb 2009 06:00:00 PST http://www.medicalnewstoday.com/articles/137853.php http://www.medicalnewstoday.com/articles/137853.php Oral tissue engineering for transplantation to aid wound healing in mouth (oral cavity) reconstruction has taken a significant step forward with a Netherlands-based research team's successful development of a gum tissue (gingival) substitute that can be used for reconstruction in the oral cavity. Their work was reported in the current issue of Cell Transplantation (17:10/11). According to the study's lead author, Dr. Transplants / Organ Donations Wed, 14 Jan 2009 07:00:00 PST http://www.medicalnewstoday.com/articles/135442.php http://www.medicalnewstoday.com/articles/135442.php The work of Forsyth scientist Peter Jezewski, DDS, Ph.D., has revealed that duplication and diversification of protein regions ('modules') within ancient master control genes is key to the understanding of certain birth disorders. Tracing the history of these changes within the proteins coded by the Msx gene family over the past 600 million years has also provided additional evidence for the ancient origin of the human mouth. Dr. Genetics Wed, 24 Dec 2008 01:00:00 PST http://www.medicalnewstoday.com/articles/133741.php http://www.medicalnewstoday.com/articles/133741.php Smoking during the first trimester of pregnancy is clearly linked with an increased risk of cleft lip in newborns. Genes that play a role in detoxification of cigarette smoke do not appear to be involved. This is shown in a new study published in the journal Epidemiology. Oral clefts are one of the most common birth defects. Closure of the lip occurs about 5 weeks into pregnancy, followed by closure of the palate at week 9. Cleft Palate Wed, 05 Nov 2008 06:00:00 PST http://www.medicalnewstoday.com/articles/128282.php http://www.medicalnewstoday.com/articles/128282.php Babies whose mothers smoked during pregnancy were more than twice as likely to have a cleft palate or lip as those whose mothers didn't, according to research results released today. Although the study confirms earlier findings, it is unique because it did not rely on women's self-reported smoking habits during pregnancy. Instead, researchers used the more reliable method of measuring the levels of cotinine, a metabolite of nicotine, in the blood from about 500 pregnant women. Smoking / Quit Smoking Tue, 07 Oct 2008 08:00:00 PST http://www.medicalnewstoday.com/articles/124553.php http://www.medicalnewstoday.com/articles/124553.php University of Iowa researchers and collaborators have found, in a previously identified gene, a variation that likely contributes to one in five cases of isolated cleft lip. It is the first time a genetic variant has been associated with cleft lip alone, rather than both cleft lip and palate. Cleft Palate Tue, 16 Sep 2008 03:00:00 PST http://www.medicalnewstoday.com/articles/121578.php http://www.medicalnewstoday.com/articles/121578.php For the first time, researchers from the University of Pittsburgh School of Dental Medicine have identified a series of genetic mutations that appear to be linked to significant risk for cleft palate and other dental abnormalities. These are devastating conditions that cause tremendous social isolation, and also are associated with decreased lifespan, a higher risk of cancer and increased susceptibility to psychiatric disorders, even after surgical repair. Cleft Palate Tue, 12 Aug 2008 02:00:00 PST http://www.medicalnewstoday.com/articles/117928.php http://www.medicalnewstoday.com/articles/117928.php Researchers at the University Of Southern California School Of Dentistry have uncovered another clue behind the causes of cleft palate and the process that leads to palate formation. Cleft palate is one of the most common congenital birth defects, occurring in one out of every 700 live births. Clefts are more common in children of American Indian, Hispanic or Asian descent. While males are twice as likely to have a cleft lip, females are twice as likely to have a cleft palate. Cleft Palate Fri, 01 Aug 2008 03:00:00 PST http://www.medicalnewstoday.com/articles/116881.php http://www.medicalnewstoday.com/articles/116881.php A new study by researchers at the National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health, shows that pregnant women who binge drink early in their pregnancy increase the likelihood that their babies will be born with oral clefts. Pregnancy / Obstetrics Thu, 05 Jun 2008 09:00:00 PST http://www.medicalnewstoday.com/articles/109994.php http://www.medicalnewstoday.com/articles/109994.php "More than a dozen health bills are advancing through the [California] Legislature," some of which contain elements of a health care overhaul plan backed by Gov. Arnold Schwarzenegger (R) that passed the state Assembly but was rejected in the Senate earlier this year, the Health Insurance / Medical Insurance Tue, 13 May 2008 05:00:00 PST http://www.medicalnewstoday.com/articles/107273.php http://www.medicalnewstoday.com/articles/107273.php Research by Dr. Damir Matic, a scientist with Lawson Health Research Institute in London, Ontario is changing the way cleft palate surgeries are performed throughout North America and around the world. Matic has been conducting research to determine the optimal time to close the gum tissue of cleft palate patients. His research suggests that it is best to wait until the child is older. Cleft Palate Thu, 24 Apr 2008 02:00:00 PST http://www.medicalnewstoday.com/articles/105168.php http://www.medicalnewstoday.com/articles/105168.php In a collaborative effort, researchers from Boston University School of Medicine (BUSM) have discovered that deletions or mutations within the TFAP2A gene (Activating Enhancer-Binding Protein) result in the distinctive clefting disorder Branchio-Oculo-Facial syndrome (BOFS). This rare disorder is characterized by specific skin anomalies involving the neck and behind the ear, eye abnormalities, a typical facial appearance, and frequently cleft lip and palate. Cleft Palate Sun, 30 Mar 2008 11:00:00 PST http://www.medicalnewstoday.com/articles/102060.php http://www.medicalnewstoday.com/articles/102060.php Following is a summary of the keynote presentations, symposia, and workshops that will anchor the 37th Annual Meeting of the American Association for Dental Research, convening April 2 at the Hilton Anatole Hotel. Keynote Presentations Wednesday, April 2 * "Optimizing the Survival of Ceramic Prostheses: Lessons Learned from the Analysis of Clinical Failures", Susanne Scherrer (University of Geneva, Switzerland), 3:15 p.m. Dentistry