Copyright 2009 Medical News Today Latest Colorectal Cancer News From Medical News Today. http://www.medicalnewstoday.com/sections/colorectal_cancer/ admin@medicalnewstoday.com (MNT Admin) editors@medicalnewstoday.com (MNT Editors) en-us Thu, 02 Jul 2009 01:00:00 PDT http://www.medicalnewstoday.com/articles/156079.php http://www.medicalnewstoday.com/articles/156079.php Pfizer Inc announced the discontinuation of the SUN 1122 Phase 3 trial that evaluated Sutent® (sunitinib malate) plus FOLFIRI (irinotecan plus infusional 5-fluorouracil and leucovorin) versus FOLFIRI alone for the first-line treatment of metastatic colorectal cancer (CRC). Colorectal Cancer Thu, 02 Jul 2009 00:00:00 PDT http://www.medicalnewstoday.com/articles/156062.php http://www.medicalnewstoday.com/articles/156062.php Previously, only a few genes had been associated with the formation of metastases in colorectal cancer. Now, researchers of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch and Charité - University Medicine Berlin, Germany, have identified 115 genes that are disregulated both in the primary tumor and in its metastases. In the future, their findings may help identify patients with aggressive tumors at an earlier stage (Gastroenterology 2009, doi:10.1053/j.gastro.2009. Colorectal Cancer Wed, 01 Jul 2009 00:00:00 PDT http://www.medicalnewstoday.com/articles/155891.php http://www.medicalnewstoday.com/articles/155891.php The July issue of European Urology, the official journal of the European Association of Urology, features an editorial by Lars Holmberg comparing the results from the European Randomised Study of Screening for Prostate Cancer (ERSPC) with the results from the Prostate, Lung, Colorectal and Prostate / Prostate Cancer Wed, 01 Jul 2009 00:00:00 PDT http://www.medicalnewstoday.com/articles/155898.php http://www.medicalnewstoday.com/articles/155898.php Improved communication among patients and primary care physicians increases the chances those due for colorectal cancer screening will follow their doctors' advice and complete the procedure, a University at Buffalo study has found. The research by principal investigator Thomas Feeley, Ph.D. Colorectal Cancer Tue, 30 Jun 2009 05:00:00 PDT http://www.medicalnewstoday.com/articles/155842.php http://www.medicalnewstoday.com/articles/155842.php Scientists discover novel mechanism that increases the risk of common colorectal cancer Finnish Academy Professors Lauri Aaltonen and Jussi Taipale have identified and described a mechanism whereby a single-base change in the human genome increases the risk of colorectal cancer. The focus in this study was on a common single-base variant occurring in chromosome 8, which in itself causes only a slightly increased risk of cancer. Colorectal Cancer Tue, 30 Jun 2009 04:00:00 PDT http://www.medicalnewstoday.com/articles/155826.php http://www.medicalnewstoday.com/articles/155826.php The decision to use expensive cancer therapies that typically produce only a relatively short extension of survival is a serious ethical dilemma in the U.S. that needs to be addressed by the oncology community, according to a commentary published online June 29 in the Journal of the National Cancer Institute. Tito Fojo, M.D., Ph.D., of the Medical Oncology Branch, Center of Cancer Research at the National Cancer Institute, in Bethesda, Md., and Christine Grady, Ph.D. Cancer / Oncology Sat, 27 Jun 2009 00:00:00 PDT http://www.medicalnewstoday.com/articles/155598.php http://www.medicalnewstoday.com/articles/155598.php Any cancer - a growth, lump, tumor - of the colon and the rectum is a type of colorectal cancer. Colorectal cancer is also known as bowel cancer. The UK National Health Service says colorectal cancer is the most common cancer globally today. However, the World Health Organization says it is the second most common cancer, after lung cancer. Colorectal Cancer Fri, 26 Jun 2009 00:00:00 PDT http://www.medicalnewstoday.com/articles/155342.php http://www.medicalnewstoday.com/articles/155342.php A new study suggests that a drop in colorectal cancer incidence seen nationwide has not occurred among people living in poorer communities, and suggests that barriers to health care may be to blame. The study appears online in the journal Cancer Causes and Control. Colorectal cancer (CRC) incidence rates have decreased rapidly in the United States since 1998, in large part from the use of endoscopic screening, which can detect and remove polyps before they turn into cancer. Colorectal Cancer Fri, 26 Jun 2009 00:00:00 PDT http://www.medicalnewstoday.com/articles/155381.php http://www.medicalnewstoday.com/articles/155381.php Prostasin, a relatively unknown protease enzyme expressed in most epithelial cells, may play a role in the genesis of colorectal cancer. Researchers writing in the open access journal BMC Cancer have associated a reduction in the expression of inhibitors of the enzyme with malignant cellular behavior. Colorectal Cancer Thu, 25 Jun 2009 04:00:00 PDT http://www.medicalnewstoday.com/articles/155297.php http://www.medicalnewstoday.com/articles/155297.php Latest Erbitux® (cetuximab) data presented today at the World Congress on Gastrointestinal Cancer (WCGIC) reinforce the value of the targeted therapy in the treatment of metastatic colorectal cancer (mCRC) patients with KRAS wild-type (wt) tumors. Results from the CRYSTALa and CELIMb trials have provided further evidence that KRAS mutation status is the current accepted standard predictive biomarker for Erbitux efficacy in patients with mCRC. Colorectal Cancer Tue, 23 Jun 2009 07:00:00 PDT http://www.medicalnewstoday.com/articles/155015.php http://www.medicalnewstoday.com/articles/155015.php Enzon Pharmaceuticals, Inc. (Nasdaq: ENZN) announced that it has opened its first Phase II trial for PEG-SN38 (EZN-2208), its novel proprietary cancer compound. The trial is open at multiple centers throughout the United States for patients diagnosed with metastatic colon cancer. "We are pleased to have the first PEG-SN38 Phase II trial open in early summer as promised," said Jeffrey H. Buchalter, Enzon's chairman and chief executive officer. Colorectal Cancer Mon, 22 Jun 2009 11:00:00 PDT http://www.medicalnewstoday.com/articles/154887.php http://www.medicalnewstoday.com/articles/154887.php ORLANDO - Cisplatin/S-1 (CS) is non-inferior to cisplatin/5-fluorouracil (CF) for the treatment of advanced gastric/gastro-esophageal carcinoma and at the same time offers important safety improvements, according to phase III results released recently at a meeting of the American Society for Clinical Oncology (ASCO). Cancer / Oncology Mon, 22 Jun 2009 05:00:00 PDT http://www.medicalnewstoday.com/articles/154846.php http://www.medicalnewstoday.com/articles/154846.php With an extensive, inoperable colon cancer and few options available, a Tennessee patient is seeing his cancer steadily regressing on a new outpatient treatment. Individuals from 26 U.S. states and four other countries have been among the first to use NeoPlas Innovation's new protocol. The Tennessee patient's early results mirror their successes in battling colon cancer and other very aggressive malignancies. Colorectal Cancer Mon, 22 Jun 2009 03:00:00 PDT http://www.medicalnewstoday.com/articles/154804.php http://www.medicalnewstoday.com/articles/154804.php More pre-cancerous polyps were found in colonoscopies performed with deep sedation primarily using Propofol than with milder sedation in which patients remained conscious, according to a recent study conducted by Katherine Hoda, M.D. of Oregon Health and Science University. This improvement in cancer detection will save lives and reduce the number of patients requiring surgery and chemotherapy. Colorectal Cancer Fri, 19 Jun 2009 02:00:00 PDT http://www.medicalnewstoday.com/articles/154544.php http://www.medicalnewstoday.com/articles/154544.php Researchers have identified a new candidate tumor suppressor gene in colorectal cancer and examined its use as a potential biomarker in stool samples, according to a new study published online June 17 in the Journal of the National Cancer Institute. In the study, Manon van Engeland, Ph.D. Colorectal Cancer Fri, 19 Jun 2009 00:00:00 PDT http://www.medicalnewstoday.com/articles/154532.php http://www.medicalnewstoday.com/articles/154532.php Researchers have identified a new candidate tumor suppressor gene in colorectal cancer and examined its use as a potential biomarker in stool samples, according to a new study published online June 17 in the Journal of the National Cancer Institute. In the study, Manon van Engeland, Ph.D. Colorectal Cancer Thu, 18 Jun 2009 00:00:00 PDT http://www.medicalnewstoday.com/articles/154328.php http://www.medicalnewstoday.com/articles/154328.php Computed tomographic (CT) colonography may offer patients at increased risk of colorectal cancer an alternative to colonoscopy that is less-invasive, is better-tolerated and has good diagnostic accuracy, according to a study in the June 17 issue of JAMA. Colorectal cancer (CRC) accounts for approximately 210,000 deaths each year in Europe. CT colonography is a procedure in which a detailed picture of the colon is created by an x-ray machine linked to a computer. Colorectal Cancer Wed, 17 Jun 2009 01:00:00 PDT http://www.medicalnewstoday.com/articles/154166.php http://www.medicalnewstoday.com/articles/154166.php Calcium Supplementation Has No Weight-loss Benefit for Obese Patients One in three American adults is overweight or obese, with a body mass index (BMI) of 25 or greater. As the obesity rate continues to rise, researchers seek an approach that can prevent weight gain or promote weight loss. Some studies suggest that people who eat more dairy products weigh less. Dairy products are a good source of calcium. Obesity / Weight Loss / Fitness Wed, 17 Jun 2009 00:00:00 PDT http://www.medicalnewstoday.com/articles/154127.php http://www.medicalnewstoday.com/articles/154127.php More pre-cancerous polyps were found in colonoscopies performed with deep sedation primarily using Propofol than with milder sedation in which patients remained conscious, according to a recent study conducted by Katherine Hoda, M.D. of Oregon Health and Science University. This improvement in cancer detection will save lives and reduce the number of patients requiring surgery and chemotherapy. Colorectal Cancer Tue, 16 Jun 2009 03:00:00 PDT http://www.medicalnewstoday.com/articles/154013.php http://www.medicalnewstoday.com/articles/154013.php People who suffer from Peutz-Jeghers syndrome, a rare inherited cancer syndrome, develop gastrointestinal polyps and are predisposed to colon cancer and other tumor types. Carefully tracing the cellular chain-of-command that links nutrient intake to cell growth (and which is interrupted in Peutz-Jeghers syndrome), allowed researchers at the Salk Institute for Biological Studies to exploit the tumors' weak spot. Colorectal Cancer Tue, 16 Jun 2009 03:00:00 PDT http://www.medicalnewstoday.com/articles/154019.php http://www.medicalnewstoday.com/articles/154019.php The United Kingdom's National Institute for Health and Clinical Excellence (NICE) has published a Final Appraisal Determination (FAD) recommending the use of the drug Erbitux® (cetuximab) in combination with chemotherapy as a first-line treatment for patients with metastatic (advanced) colorectal cancer (mCRC) who have met specific additional criteria(1) - presenting the possibility of potentially curative surgery. Colorectal Cancer Sat, 13 Jun 2009 00:00:00 PDT http://www.medicalnewstoday.com/articles/153587.php http://www.medicalnewstoday.com/articles/153587.php Colorectal cancer (CRC) is one of the most common cancers in China. Although the association between the epidemiological factors and sporadic colorectal cancer has been studied, the relation between smoking, alcohol drinking, family history of cancer, body mass index (BMI) and sporadic colorectal cancer still remains uncertain. So it is important to investigate the role of these factors in the development of sporadic colorectal cancer. Colorectal Cancer Sat, 13 Jun 2009 00:00:00 PDT http://www.medicalnewstoday.com/articles/153655.php http://www.medicalnewstoday.com/articles/153655.php New research published in the June issue of the Journal of the American College of Surgeons shows that a risk calculator developed by the American College of Surgeons (ACS) can help surgeons provide patients with more detailed and accurate preoperative information about the risk of death and complications following colorectal surgery. The tool will also allow surgeons to adjust risk probabilities for patients based on their hospital's performance during prior years. Colorectal Cancer Fri, 12 Jun 2009 07:00:00 PDT http://www.medicalnewstoday.com/articles/153710.php http://www.medicalnewstoday.com/articles/153710.php University of Florida researchers have come up with a new gene therapy method to disrupt cancer growth by using a synthetic protein to induce blood clotting that cuts off a tumor's blood and nutrient supply. In mice implanted with human colorectal cancer cells, tumor volume decreased 53 percent and cancer cell growth slowed by 49 percent in those treated with a gene that encodes for the artificial protein, compared with those that were untreated. Colorectal Cancer Fri, 12 Jun 2009 03:00:00 PDT http://www.medicalnewstoday.com/articles/153574.php http://www.medicalnewstoday.com/articles/153574.php Biothera has initiated a Phase II clinical trial in stage IV KRAS-mutated colorectal cancer patients with its investigational drug Imprime PGG® in combination with Erbitux® (cetuximab), the company announced today. Published research demonstrates that colorectal cancers with mutated KRAS genes do not respond to anti-EGFR monoclonal antibodies such as Erbitux®. Colorectal Cancer