Copyright 2009 Medical News Today Latest Gout News From Medical News Today. http://www.medicalnewstoday.com/sections/gout/ admin@medicalnewstoday.com (MNT Admin) editors@medicalnewstoday.com (MNT Editors) en-us Sat, 20 Jun 2009 01:00:00 PDT http://www.medicalnewstoday.com/articles/154718.php http://www.medicalnewstoday.com/articles/154718.php Having partnered last year with an international team that surveyed the genomes of 12,000 individuals to find a genetic cause for gout, Johns Hopkins scientists now have shown that the malfunctioning gene they helped uncover can lead to high concentrations of blood urate that forms crystals in joint tissue, causing inflammation and pain the hallmark of this disease. Gout Fri, 19 Jun 2009 07:00:00 PDT http://www.medicalnewstoday.com/articles/154658.php http://www.medicalnewstoday.com/articles/154658.php Having partnered last year with an international team that surveyed the genomes of 12,000 individuals to find a genetic cause for gout, Johns Hopkins scientists now have shown that the malfunctioning gene they helped uncover can lead to high concentrations of blood urate that forms crystals in joint tissue, causing inflammation and pain - the hallmark of this disease. Gout Wed, 17 Jun 2009 04:00:00 PDT http://www.medicalnewstoday.com/articles/154203.php http://www.medicalnewstoday.com/articles/154203.php Savient Pharmaceuticals, Inc. (Nasdaq: SVNT) announced that the Arthritis Advisory Committee appointed by the U.S. Food and Drug Administration (FDA) recommended by a vote of 14 to 1 that KRYSTEXXA(TM) (pegloticase), a biologic PEGylated uricase enzyme, be granted marketing approval by the FDA for the treatment of refractory chronic gout. Gout Sun, 14 Jun 2009 03:00:00 PDT http://www.medicalnewstoday.com/articles/153784.php http://www.medicalnewstoday.com/articles/153784.php Ardea Biosciences, Inc. (Nasdaq:RDEA) announced positive interim results from an ongoing Phase 2a, proof-of-concept study of RDEA594, its lead product candidate for the treatment of hyperuricemia and gout, as well as additional positive results from completed Phase 1 studies of RDEA594 in normal, healthy volunteers. Gout Sat, 06 Jun 2009 00:00:00 PDT http://www.medicalnewstoday.com/articles/152679.php http://www.medicalnewstoday.com/articles/152679.php Researchers at the University of California, San Diego School of Medicine have developed the first mouse model for auto-inflammatory diseases, disorders that involve the over-activation of the body's innate, primitive immune system. Their study, published early on-line in Cell Immunity on June 4, suggests that the innate - not adaptive - immune system drives auto-inflammatory diseases. Immune System / Vaccines Fri, 05 Jun 2009 00:00:00 PDT http://www.medicalnewstoday.com/articles/152620.php http://www.medicalnewstoday.com/articles/152620.php The most reliable method of diagnosing gout is to aspirate the joint in order to obtain fluid to verify the presence of monosodiumurate crystals (uric acid). Up to now, computed tomography (CT) has played a limited role in the evaluation of gout, since conventional CT systems cannot reliably verify deposits of uric acid. Gout Mon, 01 Jun 2009 15:00:00 PDT http://www.medicalnewstoday.com/articles/152120.php http://www.medicalnewstoday.com/articles/152120.php Bursitis happens when the bursa is inflamed. The burse acts as a cushion between bones, tendons, joints and muscles - bursae are fluid-filled sacs (the plural of bursa is bursae). People with bursitis will feel pain at the site of inflammation. The medical word "bursa" comes from the Latin bursa, meaning a purse, which is what a bursa resembles. According to Medilexicon's Pain / Anesthetics Thu, 28 May 2009 07:00:00 PDT http://www.medicalnewstoday.com/articles/151742.php http://www.medicalnewstoday.com/articles/151742.php The most reliable method of diagnosing gout is to aspirate the joint in order to obtain fluid to verify the presence of monosodium urate crystals (uric acid). Up to now, computed tomography (CT) has played a limited role in the evaluation of gout, since conventional CT systems cannot reliably verify deposits of uric acid. Gout Sat, 23 May 2009 01:00:00 PDT http://www.medicalnewstoday.com/articles/151178.php http://www.medicalnewstoday.com/articles/151178.php The Gout & Uric Acid Education Society announced that new survey results reveal alarming gaps in the public's awareness of gout, a painful and potentially debilitating form of arthritis that affects three to five million Americans. In a survey of more than 2,000 Americans, 65% of adults admitted to being "not at all knowledgeable" about gout and just over 70% did not know that gout is a form of arthritis. In fact, gout is the most common form of inflammatory arthritis among adults. Gout Thu, 02 Apr 2009 07:00:00 PDT http://www.medicalnewstoday.com/articles/144827.php http://www.medicalnewstoday.com/articles/144827.php The word gout comes from Latin gutta and old French gote meaning "a drop". Several hundred years ago gout was thought to be caused by drops of viscous humors that seeped from blood into the joints. In fact, this supposition was not that far from the truth. When a patient experiences the symptoms of a gout attack uric acid has been accumulating in his blood, and uric acid deposits have been forming in the joints. Gout Mon, 09 Mar 2009 13:00:00 PDT http://www.medicalnewstoday.com/articles/141562.php http://www.medicalnewstoday.com/articles/141562.php Men with higher vitamin C intake appear less likely to develop gout, a painful type of arthritis, according to a report in the March 9 issue of Archives of Internal Medicine, one of the JAMA/Archives journals. "Gout is the most common type of inflammatory arthritis in men," the authors write as background information in the article. "Epidemiologic studies suggest that the overall disease burden of gout is substantial and growing. Gout Mon, 16 Feb 2009 03:00:00 PDT http://www.medicalnewstoday.com/articles/139130.php http://www.medicalnewstoday.com/articles/139130.php The US Food and Drug Administration has given marketing approval to a new drug that lowers levels of uric acid in the blood of patients with gout: the current treatment for the condition was developed over 40 years ago. The new drug is called ULORIC (generic name febuxostat) and Takeda Pharmaceuticals North America is the sole developer and marketer of the product in the US. Gout Mon, 16 Feb 2009 03:00:00 PDT http://www.medicalnewstoday.com/articles/139133.php http://www.medicalnewstoday.com/articles/139133.php Takeda Pharmaceutical Company Limited and its wholly-owned subsidiary, Takeda Pharmaceuticals North America, Inc., announced today that the United States Food and Drug Administration (FDA) has approved ULORIC(R) (febuxostat) 40 mg and 80 mg for the chronic management of hyperuricemia in patients with gout. Gout Wed, 14 Jan 2009 00:00:00 PDT http://www.medicalnewstoday.com/articles/135285.php http://www.medicalnewstoday.com/articles/135285.php Ardea Biosciences, Inc. (Nasdaq:RDEA) announced positive results from a completed single ascending dose (SAD) Phase 1 clinical study of RDEA594, its lead product candidate for the treatment of hyperuricemia and gout. The study was conducted in normal healthy volunteers with serum uric acid above 5.0 mg/dL. Gout Wed, 07 Jan 2009 05:00:00 PDT http://www.medicalnewstoday.com/articles/134673.php http://www.medicalnewstoday.com/articles/134673.php Risk factors for gout include family history, older age, renal insufficiency, use of medications that reduce urate excretion, high intake of foods that increase urate production (beer, seafood, red meat, high-fructose beverages), and comorbidities such as obesity and metabolic syndrome. About 90% of acute gout attacks are monoarticular; 50% occur in the first metatarsophalangeal joint. Pain, redness, and swelling peak in 1 day. Gout Tue, 25 Nov 2008 04:00:00 PDT http://www.medicalnewstoday.com/articles/130736.php http://www.medicalnewstoday.com/articles/130736.php Takeda Pharmaceutical Company Limited and its wholly-owned subsidiary, Takeda Global Research & Development Center, Inc., U.S., announced today that the Arthritis Advisory Committee of the U.S. Food and Drug Administration (FDA) recommended that the FDA approve febuxostat for the treatment of hyperuricemia in patients with gout. The vote was 12 to zero in favor of approval, with one panel member abstaining. Gout Wed, 05 Nov 2008 01:00:00 PDT http://www.medicalnewstoday.com/articles/128178.php http://www.medicalnewstoday.com/articles/128178.php The goal in treating patients with gout is to reduce acute attacks by lowering serum urate levels, which are usually high in this disease. At the same time, high serum urate levels have been shown to lower the risk of developing Parkinson's disease (PD). A new study compared the safety and efficacy of febuxostat, a new drug being developed for gout that was recently approved for use in Europe, and a commonly used drug that has been around for years. Gout Fri, 31 Oct 2008 02:00:00 PDT http://www.medicalnewstoday.com/articles/127621.php http://www.medicalnewstoday.com/articles/127621.php A fungus called microsporidia that causes chronic diarrhea in AIDS patients, organ transplant recipients and travelers has been identified as a member of the family of fungi that have been discovered to reproduce sexually. A team at Duke University Medical Center has proven that microsporidia are true fungi and that this species most likely undergoes a form of sexual reproduction during infection of humans and other host animals. Biology / Biochemistry Tue, 07 Oct 2008 09:00:00 PDT http://www.medicalnewstoday.com/articles/124567.php http://www.medicalnewstoday.com/articles/124567.php An international team of researchers led by Professors Mark Caulfield and Patricia Munroe, from the William Harvey Research Institute at Barts and The London School of Medicine and Dentistry with Chris Cheeseman at the University of Alberta in Canada and Kelle Moley at the University of Washington in USA, have shown that the SLC2A9 gene, which encodes a glucose transporter, is also a high-capacity urate transporter, and thus possibly a new drug target for gout. Gout Thu, 02 Oct 2008 01:00:00 PDT http://www.medicalnewstoday.com/articles/123852.php http://www.medicalnewstoday.com/articles/123852.php Researchers have identified two new genes - and confirmed the role of a third gene - associated with increased risk of higher levels of uric acid in the blood, which can lead to gout, a common, painful form of arthritis. Combined, the three genetic variations were associated with up to a 40-fold increased risk in developing gout. Gout Thu, 02 Oct 2008 00:00:00 PDT http://www.medicalnewstoday.com/articles/123765.php http://www.medicalnewstoday.com/articles/123765.php According to an article published early online and in an upcoming edition of The Lancet, researchers have gained new insights into the genetic properties of gout. Dr Caroline Fox (National Heart Lung and Blood Institute, Bethesda, MD, USA) and colleagues demonstrate that three genes are linked to an increased risk of gout. Well before onset of clinical symptoms, doctors can analyze a genetic risk score based on these genes to find those at highest risk of the condition. Gout Tue, 24 Jun 2008 13:00:00 PDT http://www.medicalnewstoday.com/articles/112620.php http://www.medicalnewstoday.com/articles/112620.php If you are planning to go to the Glastonbury music festival this weekend and your prayers for a dry and warm few days aren't answered, you might like to heed BBC reporter Andy Sully's advice and look after your feet, or you could end up with trench foot, as he did last year. The Glastonbury Festival of Contemporary Performing Arts, better known as Glastonbury or Glasto, is the largest music and performing arts festival of its kind in the world. Primary Care / General Practice Tue, 06 May 2008 02:00:00 PDT http://www.medicalnewstoday.com/articles/106338.php http://www.medicalnewstoday.com/articles/106338.php Ipsen (Paris:IPN) announced that the European Commission granted marketing authorisation for Adenuric® (febuxostat) for the treatment of chronic hyperuricaemia in gout. Adenuric® thus pioneers the first major treatment alternative for gout, a severe debilitating disease, for more than 40 years. Gout Wed, 19 Mar 2008 05:00:00 PDT http://www.medicalnewstoday.com/articles/101082.php http://www.medicalnewstoday.com/articles/101082.php For patients with type 1 diabetes, increased levels of uric acid in the blood may be an early sign of diabetic kidney disease - appearing before any significant change in urine albumin level, the standard screening test, reports a study in the May 2008 issue of the Clinical Journal of the American Society of Nephrology. The results raise the possibility that treatments to reduce uric acid might slow the decline of renal function in patients with diabetes. Diabetes Mon, 10 Mar 2008 07:00:00 PDT http://www.medicalnewstoday.com/articles/100073.php http://www.medicalnewstoday.com/articles/100073.php A study led by a team of scientists in Scotland suggests that genes may play a part in increasing one's risk of developing gout, a painful condition that affects the joints. The study is published in the 9 March online issue of Nature Genetics and is the work of researchers based at the MRC Human Genetics Unit, Western General Hospital, Edinburgh, and colleagues from other research centres in the UK and also in Croatia and Germany. Gout