Huntington’s disease is a rare and incurable hereditary disorder that damages brain cells. Early signs include coordination problems and memory lapses. In the later stages, people may need full-time care.

Huntington’s disease (HD) is an inherited neurological condition that happens when a gene mutation causes toxic proteins to collect in different parts of the brain.

HD, also known as Huntington’s chorea, leads to symptoms that may impact movement, behavior, and cognition.

According to the Genetic and Rare Diseases Information Center (GARD), less than 5,000 people in the United States are living with HD.

This article discusses the symptoms and causes of HD, as well as various methods to help a person manage their symptoms.

HD causes a variety of physical, behavioral, and cognitive symptoms that typically appear in people aged 30–50.

However, 5-10% of people with HD develop symptoms before age 20. This is called juvenile Huntington’s disease and may progress more quickly.

Approximately 4–11% develop HD symptoms after 60.

The types, frequency, and severity of HD symptoms may also vary between individuals. For example, some may experience depression first and then changes in their motor skills, while others may show physical signs.

Physical symptoms

HD may cause symptoms that affect a person’s stature and gait, as well as voluntary and involuntary movements.

Other symptoms of HD may include:

  • difficulty speaking, swallowing (dysphagia), or eating
  • weight loss, which may weaken a person’s immune system
  • difficulty walking, such as stumbling or losing balance
  • rigidity, which is more common in juvenile HD

Chorea is the most common involuntary symptom of adult HD. These are uncontrollable movements like spasms, jerks, and twitches that may affect any body part.

Other involuntary symptoms of HD may include:

  • akinesia
  • loss of coordination and control of movements
  • seizures, which are more common in juvenile HD
  • unusual eye movements
  • dystonia
  • Babinski reflex
  • clonus

Over time, uncontrollable movements occur more often and usually with more intensity. Eventually, they may become slower as the muscles become more rigid.

Behavioral symptoms

Approximately 40% of people with HD will develop depression at some point.

Other mental health conditions that may affect people with HD include:

  • obsessive-compulsive disorder (OCD)
  • mania
  • delusional disorders

Other behavioral symptoms of HD could include:

  • aggression, hostility, or frustration
  • insomnia
  • polyphagia
  • irritability
  • moodiness
  • hypersomnolence
  • alcohol-use disorder
  • stubbornness

Cognitive symptoms

HD may cause brain alterations that could affect a person’s emotional and cognitive functions, including:

  • memory loss
  • apathy
  • hallucinations
  • lethargy
  • brain fog
  • a reduction of organizational skills
  • confusion or disorientation
  • difficulty focusing, multitasking, or driving
  • trouble learning new things

Cognitive symptoms typically worsen over time and may lead to dementia. Eventually, someone may require full-time care.

According to the Huntington’s Disease Society of America (HDSA), the risk of suicide in people with HD is up to 10 times higher than the national average.

The HDSA recommends that loved ones and caregivers of people with HD are aware of the signs of suicide ideation.

Suicide prevention

If you know someone at immediate risk of self-harm, suicide, or hurting another person:

  • Ask the tough question: “Are you considering suicide?”
  • Listen to the person without judgment.
  • Call 911 or the local emergency number, or text TALK to 741741 to communicate with a trained crisis counselor.
  • Stay with the person until professional help arrives.
  • Try to remove any weapons, medications, or other potentially harmful objects.

If you or someone you know is having thoughts of suicide, a prevention hotline can help. The 988 Suicide and Crisis Lifeline is available 24 hours a day at 988. During a crisis, people who are hard of hearing can use their preferred relay service or dial 711 then 988.

Find more links and local resources.

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HD results from a gene mutation on chromosome 4 of huntingtin (HTT).

This genetic mutation is caused by the excessive production – or trinucleotide repeats – of cytosine, adenine, and guanine (CAG). These are three building blocks of DNA.

Normally, CAG repeats 36 times or less. But, in HD it repeats 36 times or more.

This change results in a longer form of the HTT protein, which is then cut into small harmful cells that could bind together. As the toxic protein accumulates in the brain, it begins to damage certain brain cells. This causes symptoms.

If the repetition is 36–39, a person may or may not develop HD. If it repeats 40 times or more, a person will almost certainly develop the condition.

How is Huntington’s disease passed on?

HD is an autosomal dominant disorder. This means a person may have it if they inherit one copy of the mutated gene from either parent.

A person with the gene mutation has one typical copy of the gene and one mutated copy. Any offspring will inherit either the typical copy or the mutated one. A child who inherits the typical copy will not develop HD, while a child who inherits the mutated copy will.

Each child has a 50% chance of inheriting the gene mutation. If they inherit the gene with the mutation, their children will also have a 50% chance of inheriting it.

A person who does not inherit the gene mutation will not develop the disease and cannot pass it on to their children.

To diagnose HD, a doctor will perform a physical examination and ask a person about their symptoms, and family and medical history.

A combination of physical, behavioral, and cognitive symptoms along with confirmed HD in a person’s family is usually enough to diagnose HD.

However, it may be hard to diagnose symptoms of HD if none of the person’s family members have previously received a diagnosis.

To rule out other diseases, a doctor may perform further tests, such as:

  • Laboratory: These may help a doctor rule out other conditions that may cause similar symptoms.
  • Magnetic resonance imaging (MRI): An MRI may help identify changes in the brain structure, as it may show signs before clinical manifestations appear.
  • Genetic tests: These test for CAG repetitions and are the gold standard test.

If a doctor thinks a person may have HD, they will refer them to a neurologist.

HD is currently incurable. Treatment cannot reverse its progression or slow it down.

However, medication and other therapies may help people manage some of their symptoms.


Tetrabenazine (Xenazine) and deutetrabenazine (Austedo) are two drugs that have been approved by the Food and Drug Administration (FDA) to help treat involuntary movements that may occur with HD.

They may pose side effects that could be harmful. If a person has signs of depression or mood changes when taking these drugs, they should contact a doctor.

Antipsychotic drugs may help control movements, outbursts, and hallucinations. These may include:

  • clonazepam (Klonopin)
  • haloperidol
  • clozapine (Clorazil)

Psychotropic medications may help manage psychological symptoms and disorders. These may include:

Other drugs that may benefit people with HD are currently undergoing clinical trials.

Speech therapy

Huntington’s disease may cause severe problems with controlling the muscles of the throat and mouth. This could make it difficult for the person to speak, swallow, and eat.

Speech therapy may help a person improve these skills and reduce the resulting challenges.

A speech therapist could also teach a non-verbal person how to communicate without speaking, for example, by using a board with images of items and activities in everyday life.

Physical and occupational therapy

A physical therapist may help improve a person’s muscle strength, flexibility, and balance.

They can develop and modify a person’s exercise plan to meet a person’s changing physical state. A therapist may also advise them on using supporting devices like a wheelchair or walker.

An occupational therapist may assist the person with additional supportive devices that help with daily functioning, such as handrails throughout the home, specialized eating and drinking utensils, and devices that help a person shower or dress.

Genetic testing for HD became possible in 1993. Anyone with a family history of the disease can ask a doctor about testing to determine whether they carry the gene mutation.

If people want to have a child and one parent has the gene mutation, they can have in-vitro fertilization (IVF) treatment. The embryo is then genetically tested in a laboratory and doctors only transfer it if it does not have the gene mutation.

A fetus may also undergo genetic testing during gestation if there is a family history of the disease. Doctors do this using a tissue sample from the placenta at 10–11 weeks, or through an amniocentesis at 14–18 weeks.

Can you live a long life with Huntington’s disease?

Most adults with HD live for 10–25 years after a diagnosis, while juvenile HD may be fatal within 10 years of a diagnosis.

What are the 4 main symptoms of Huntington’s disease?

HD is a hereditary condition that causes damage to a person’s brain cells. This may cause symptoms that are:

  • physical
  • behavioral
  • cognitive
  • emotional

Some symptoms of HD may include:

  • uncontrollable movements like jerks or twitches
  • affected posture or gait
  • memory loss
  • depression
  • agitation, irritation, or frustration
  • trouble speaking, swallowing, or eating

Huntington’s disease may have a significant impact on the lives of an individual and their loved ones.

Although there is currently no cure, researchers have been looking for ways to use gene therapy to cure, slow, or prevent HD.

In 2017, scientists from Emory University suggested that some CRISPR-Cas9 techniques may help prevent HD in the future. Experiments in mice have shown “significant improvements” after three weeks. Most traces of the damaging protein had gone, and the nerve cells showed signs of healing themselves.

Additional studies have shown that a similar approach may be successful on a cellular level, but more research is needed to determine how doctors can apply this to treat people with HD.

Meanwhile, organizations such as the HDSA offer support for people with the condition and their families.