Individuals could reduce their risk of developing liver cancer by consuming more vitamin E, either from diet or vitamin supplements, according to a new study.`
According to the study, published in the Journal of the National Cancer Institute, liver cancer is one of the leading causes of cancer mortality in world. Around 85% of liver cancers occur in developing countries, with 54% in China alone.
Wei Zhang, M.D., MPH., Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, and colleagues set out to determine the association between vitamin E intake and liver cancer risk.
The researchers examined data from 132,837 people in China who participated in the Shanghai Women’s Health Study, or the Shanghai Men’s Health study. The two studied were jointly conducted by the Shanghai Cancer Institute and Vanderbilt University.
The team gathered data on participants’ dietary habits, via surveys and in-person interviews. Study participants were asked how often they consumed some of the most popular foods in urban Shanghai and if they took vitamin supplements.
They then compared liver cancer risk among participants who had high vitamin E intake with participants who had low vitamin E intake.
The analysis included 267 liver cancer patients who were diagnosed with the disease within two years of study enrollment. Vitamin E intake from diet and supplements use were both linked with a reduced risk of developing liver cancer.
According to the researchers, this link was consistent among participants with and without self-reported liver disease or a family history of liver cancer.
The team highlighted that they found a small difference between men and women in the risk estimate, which is likely attributable to fewer liver cancer cases having occurred among male participants due to the shorter follow-up period.
Xiao Ou Shu, M.D., Ph.D., professor of Medicine at the Vanderbilt Epidemiology Center, said:
“We found a clear, inverse dose-response relation between vitamin E intake and liver cancer risk.Overall, the take home message is that high intake of vitamin E either from diet or supplements was related to lower risk of liver cancer in middle-aged or older people from China.”
The team found that participants were more likely to develop liver cancer, is they consumed extremely high levels of vitamin C from supplements, had a family history of liver cancer, or self-reported liver disease. The researchers found no association between participants who had the highest levels of vitamin C or other vitamins from food with liver cancer.
Written by Grace Rattue