Children born to mothers who have active genital herpes during pregnancy may be at twice the risk of developing autism spectrum disorder, new research suggests.
Lead author Milada Mahic, of the Center for Infection and Immunity and the Norwegian Institute of Public Health in Norway, and colleagues report their findings in the journal mSphere.
HSV-2 infection is much more common among women than men; around
According to Mahic and team, following an initial HSV-2 infection, the virus can lay dormant in nerve cells. At any time, HSV-2 can become active and cause flare-ups. As the body acquires immunity to the virus, the frequency of flare-ups may reduce over time.
Mahic and colleagues believe their study supports such findings, after finding that a mother's immune response to HSV-2 was associated with their child's risk of ASD.
Maternal immune response to HSV-2 may disrupt fetal neurodevelopment
To reach their findings, the researchers analyzed the blood samples of 875 mothers who were enrolled in the Autism Birth Cohort (ABC) Study. Of these women, 412 had children with ASD, while 463 were mothers to children without ASD.
Blood samples were collected at 18 weeks of pregnancy and again during childbirth. The researchers analyzed each sample for levels of antibodies to five pathogens: Toxoplasma gondii, rubella virus, cytomegalovirus, herpes simplex virus 1 (HSV-1), and HSV-2.
The team found that mothers who had high levels of antibodies to HSV-2 in their blood at 18 weeks of pregnancy were twice as likely to have children with ASD. High levels of antibodies to the other four pathogens were not associated with ASD risk in offspring.
The researchers note that 18 weeks of pregnancy is around the time when the nervous system of the fetus goes through rapid development. As such, they speculate that a mother's immune response to HSV-2 may interfere with fetal nervous system development, which may increase the risk of autism.
Link between maternal HSV-2, autism only evident for boys
The link between high antibody levels to HSV-2 and increased ASD risk for offspring was only seen for boys, the researchers report.
However, they point out that their study only included a small number of females with ASD, so they are unable to conclude whether their findings are sex-specific. Still, they note that ASD is much more common among boys than girls.
While further studies are needed to get a better understanding of the link between HSV-2 infection in pregnancy and ASD risk in offspring, the researchers believe their findings shed light on the underlying causes of ASD.
"The cause or causes of most cases of autism are unknown. But evidence suggests a role for both genetic and environmental factors.
Our work suggests that inflammation and immune activation may contribute to risk. Herpes simplex virus-2 could be one of any number of infectious agents involved."
Senior author W. Ian Lipkin, Center for Infection and Immunity