For many, taking antidepressants means experiencing some form of sexual dysfunction.

Experts are still researching the sexual side effects caused by antidepressants to figure out why they happen and how to prevent them. There may be some antidepressants that cause fewer sexual side effects, and there are also promising ways to manage or prevent these effects.

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Taking antidepressant drugs can cause a wide range of side effects. Everything from gut issues to anxiety have been reported by people who take antidepressants.

Until recently, the sexual side effects caused by antidepressants were not often discussed with patients before prescribing the medications.

The symptoms of sexual dysfunction caused by taking antidepressants were highlighted in a recent study posted to Drug, Healthcare and Patient Safety.

Commonly reported symptoms include:

  • decreased sexual desire
  • loss of sexual excitement
  • diminished or delayed orgasm
  • loss of sensation
  • persistent genital arousal

These symptoms can change from person to person. There are also some symptoms that are particular to men and women. In men, more specific symptoms may occur, such as trouble getting or keeping an erection, or a persistent and painful erection. Men may also experience delayed or painful ejaculation.

Specific symptoms of sexual dysfunction caused by antidepressants in women include lactation that is not due to pregnancy or breastfeeding, and numbness in the vagina and nipples.

The symptoms of sexual dysfunction can impact a person’s quality of life. This can affect relationships, decrease self-esteem, and lead some people to stop taking their medication in order to find relief from the symptoms.

However, stopping taking medication abruptly can lead to withdrawal symptoms so this is not recommended. People who are experiencing sexual side effects could try some management techniques instead.

The reason that antidepressants cause sexual side effects is not fully understood. Depression itself can cause sexual side effects as well, so it can be difficult to understand which symptoms are caused by the disorder and which are caused by the medicine.

The side effects may also be due to the fact that each drug acts in a slightly different way in the body. For instance, selective serotonin reuptake inhibitors (SSRIs) work to increase the amount of serotonin circulating in the brain.

Serotonin helps the user feel less depressed and anxious, but too much serotonin may inhibit a person’s sex drive and make it harder to experience sexual pleasure.

Another theory is that as serotonin is increased, the levels of dopamine are decreased. This would be significant because dopamine is a chemical in the body that people need to feel stimulated. With less dopamine in the body, a person may have a hard time feeling sexually aroused.

Each antidepressant medication acts differently in the body. All of the main types of antidepressant have been linked to sexual side effects. The prevalence varies by the study and specific medication, however.


While there are many people who have sexual dysfunctions when taking all types of antidepressants, it is most commonly reported with SSRIs. Brand names include Zoloft, Prozac, and Paxil, among others.

A report in Drug, Healthcare and Patient Safety indicates that 58 to 70 percent of people who take SSRIs experience sexual side effects.

Tricyclic antidepressants (TCAs)

TCAs such as amitriptyline may be a better option for many patients. Amitriptyline was linked to sexual side effects in an estimated 7.7 to 10 percent of depressed people.

It seems that TCAs are a much better option than SSRIs for people with sexual dysfunctions caused by antidepressant drugs.

5-HT2 blockers

According to the report in Drug, Healthcare and Patient Safety, people who took newer 5-HT2 blockers experienced less symptoms of sexual dysfunction than those who took SSRIs.

For example, 8 percent of people taking the drug nefazodone experienced sexual side effects, while the drug mirtazapine produced sexual side effects in 24 percent of its cases. These figures are quite a lot lower than those reported with SSRIs.

People who are interested in switching medications should talk to their doctors for full details.

Monoamine oxidase inhibitors (MAOIs)

According to a journal posted in South African Family Practice, certain MAOIs have been associated with sexual side effects. This number does depend on the type of MAOI itself.

For instance, the drug phenelzine was associated with sexual dysfunction in up to 40 percent of cases.

Reversible inhibitor or monoamine oxidase A (RIMA)

When looking to avoid sexual side effects while taking antidepressants, many users turn to the RIMA drug moclobemide. Its brand names include Aurorix, Amira, and others.

Moclobemide appears to have a much lower incidence of sexual side effects. Less than 4 percent of moclobemide users reported sexual side effects while taking the drug. The drug is common in Australia and Finland, but is not approved for use in the United States.

Sexual dysfunction does not have to be a permanent side effect of taking antidepressants. In some cases, patients experience these symptoms within the first few weeks or months of taking their prescription, and then the symptoms become less severe.

Many people on antidepressants may also find success through managing their sexual side effects in one or more ways.

Switching medication

If the side effects caused by antidepressants are severe or very persistent, it may be possible to switch medications to try out results on another medication.

Working with their doctor, an individual will gradually come off their current medication and move to a new one. After a suitable trial period, the doctor may evaluate the person to see whether to change the dosage of the medication.

Lowering dosage

The dosage of the medication may also have an effect on the sexual side effects the patient experiences. If a patient feels their dosage is too high, they can have it evaluated by their doctor.

The doctor will begin putting the patient on lower doses of the drug. They will then monitor their progress to determine the lowest dose of the drug the person can take for it to be effective. Dosage is a very individual thing, and should not be adjusted without guidance from a doctor.

Personal changes

There are also ways to raise the libido without adjusting medications.

For many people, it is the will to have sex that is most affected by antidepressant medications. They may be physically able to be aroused, yet lack the willpower to carry out the act.

In these cases, it may be helpful to allow the body to go through the motions that usually make the person feel sexually aroused. Engaging in foreplay can stimulate the body and may help to influence the mind and increase the libido naturally.

Doctors may also recommend that people who take their medication on a daily basis, engage in sexual activity before taking their medication. In some cases, adding a sexual stimulant drug may help improve sex drive. As always, people should discuss these options with a doctor.

Because antidepressants may also decrease the amount of dopamine in the body, it is important for people taking them to boost their natural levels of dopamine. This can be as simple as getting plenty of rest and exercise, while also reducing stress levels.


Many of the antidepressants on the market are linked to sexual side effects. The symptoms vary from person to person, but can greatly affect an individual’s life.

Managing these side effects can require a mixture of lifestyle changes, different medication, and dosage corrections. Working directly with a doctor, patients can help to reduce or eliminate sexual side effects caused by antidepressants.