It is a serious condition that can become steadily worse. If left untreated, psoriatic arthritis (PsA) can lead to joint destruction, disability, and impaired quality of life.
Although there is currently no cure for PsA, early diagnosis and targeted treatment plans may slow, or even halt, its progression.
PsA has traditionally been managed using a combination of nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and disease-modifying anti-rheumatic drugs (DMARDs).
Recent advances in understanding the body's immune response to PsA has led to new therapies, including the use of tumour necrosis factor inhibitors (TNFs).These have been shown to reduce the progression of joint damage in some patients.
Drug treatments for psoriatic arthritis
Drug treatments may control inflammation and relieve discomfort for people with PsA.
The current pharmacological treatment options for PsA aim to:
- control inflammation
- relieve discomfort
- prevent further damage
- improve quality of life and functional status
NSAIDs are used to relieve pain and reduce inflammation. They work by blocking the production of compounds known as prostaglandins. These signal the body's immune system to trigger an inflammatory response.
The most common over-the-counter NSAIDs are ibuprofen (Advil, Motrin) and naproxen sodium (Aleve). Stronger NSAIDs are also available by prescription.
Doctors commonly prescribe NSAIDS to people who have mild symptoms of PsA:
- swelling in fingers or toes
- swelling where ligaments attach to the bones, including the ribs, spine, and pelvis
- inflammation of the spinal column
Corticosteroids mimic the anti-inflammatory hormone cortisol, which is normally made by the body's adrenal glands. They are either taken by mouth or administered as a local injection to provide temporary inflammation relief.
However, long-term use can lead to side effects such as facial swelling, weight gain, diabetes, and weak bones.
DMARDs and biologics, a subtype of DWARDs, work to suppress the overactive immune system but may also raise the risk of infections.
DMARDs, including methotrexate, sulfasalazine, leflunomide, and cyclosporine, are frequently prescribed alongside to NSAIDs.
They help to suppress the body's overactive immune system, which causes persistent inflammation. They can take several weeks to take effect.
It works by blocking an enzyme that regulates immune and inflammatory processes. Clinical studies suggest that it is effective and generally well-tolerated.
Biologics are a special subclass of DMARDs. One group of biologics, known as TNF inhibitors, are typically only offered to people who do not respond effectively to other DMARDs. Examples include:
- adalimumab (Humira)
- certolizumab pegol (Cimzia)
- etanercept (Embrel)
- golimumab (Simponi)
- infliximab (Remicade)
Biologics work by blocking a specific protein that is produced by immune cells and which signals other cells to start the inflammatory process.
Another biologic, called ustekinumab (Stelara), works by blocking two proteins that cause inflammation. Two other biologics block another pro-inflammatory protein, these are called Ixekizumab and Secukinumab.
While biologics can be very effective, they suppress the immune system and raise the risk of infections.
Management of mild, moderate, and severe PsA
|Drug therapy||Impact of PsA on quality of life|
|Mild||NSAIDs (possibly with local corticosteroid injections)||Minimal|
|Moderate||DMARDs or TNF inhibitors||Impacts everyday tasks and physical and mental functions; does not respond to NSAIDs|
|Severe||DMARDs and TNF inhibitors||Cannot perform everyday tasks easily without pain; heavy impact on physical and mental functions; does not respond to DMARDs or TNF inhibitors as monotherapy|
Non-drug treatment options
The following non-drug management strategies are recommended in addition to drug therapy:
- Exercise: Regular exercise can help to maintain strength in the muscles. Patients should be encouraged to exercise, and referred for physical or occupational therapy where appropriate.
- Keeping weight down: Obesity and metabolic syndrome are often observed in people with PsA. These conditions are thought to make DMARDs and biologic agents less effective. People with these conditions may benefit from dietary advice and weight loss counselling.
- Healthful lifestyle: Patients with PsA should be given a set of healthful lifestyle guidelines, which include the need to moderate alcohol intake and not smoke. Appropriate stress management techniques should be discussed where appropriate.
- Patient education: Patients should be taught about their medications and how to take them properly. They should also be informed about the importance of monitoring the side effects of their medications.
Complementary and alternative therapies
Many people manage their PsA using complementary and alternative medicine (CAM) in addition to conventional treatments. People with PsA should discuss these therapies with healthcare providers before trying them.
Among the most popular are:
Acupuncture and massage may help relax the muscles and reduce stiffness and pain in the joints.
- Vitamin and mineral supplements: Doctors often recommend a good multivitamin that includes calcium, folic acid, and vitamin D for people with musculoskeletal disorders. Vitamin D, in particular, has been found to be a strong immune regulator that may benefit people with inflammatory diseases, such as psoriasis.
- Omega-3 fish oil supplement: A recent study suggests that omega-3 fatty acids also had a beneficial effect on inflammation. The study also noted that people with PsA who took omega-3 fatty acids used less painkillers.
- Herbal remedies: There is ongoing research that supports the use of turmeric extract - about 1,000 milligrams (mg) per day of curcumin - for relieving the symptoms of joint arthritis.
- Body treatments: Massage, acupuncture, and acupressure may relax muscles and ease pain and stiffness in the joints.
- Movement and mind-body therapies: Stress and tension can make symptoms worse. Meditation and yoga, which focus on deep breathing, can help patients to feel more calm and clear-headed.
Some people claim that an alkaline diet may reduce inflammation in the body. An alkali diet is one where the focus is on eating alkaline foods, such as whole fruits and vegetables instead of more acidic foods, such as meat and dairy products.
A healthful diet also helps to prevent heart disease, which is a risk factor for people with PsA.
Management of PsA usually involves a combination of NSAIDs, corticosteroid injections, or a combination of the two. DMARDs and biologic therapies are prescribed for people with more severe symptoms.
The best choice of therapy will depend upon the disease severity, prior treatment, other conditions that are present, access to therapy, and patient choice.