Recent research has revealed that a new urine test can detect aggressive prostate cancer cases that need treatment up to 5 years sooner than other diagnostic methods.
Researchers from the University of East Anglia (UEA) in Norwich, United Kingdom, and the Norfolk and Norwich University Hospital (NNUH) carried out the study.
They revealed that an experimental urine test, called Prostate Urine Risk (PUR), can distinguish who will and who will not require treatment within the first 5 years of diagnosis.
The findings now appear in the journal
The team included Prof. Colin Cooper, Dr. Daniel Brewer, and Dr. Jeremy Clark, from UEA’s Norwich Medical School. Rob Mills, Marcel Hanna, and Prof. Richard Ball, of the NNUH, provided support.
To develop this unique test, the researchers looked at gene expression in the urine samples of 535 men and determined the cell-free expression of 167 different genes.
They then established a combination of 36 different genes that the scientists considered risk signatures, or biomarkers, that the PUR test could look for.
This test is unique in that it can sort people into different risk groups, thereby demonstrating the aggressiveness of the cancer.
“This research shows that our urine test could be used to not only diagnose prostate cancer without the need for an invasive needle biopsy but to identify a [person’s] level of risk,” says Dr. Clark.
“This means that we could predict whether or not prostate cancer patients already on active surveillance would require treatment. The really exciting thing is that the test predicted disease progression up to 5 years before it was detected by standard clinical methods.”
“Furthermore,” he adds, “the test was able to identify men that were up to eight times less likely to need treatment within 5 years of diagnosis.”
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For example, the prostate-specific antigen (PSA) blood test can help detect the possible presence of prostate cancer. Doctors tend to use these results, or a series of results, to determine if someone needs a biopsy.
Doctors might also perform a digital rectal exam to see if there are areas on the prostate that could be cancer. Although it is less effective than a PSA test, it can sometimes find cancers in people with normal PSA levels.
The PUR test goes one step further; it not only identifies the presence of cancer earlier than other tests, it can also help put people into different risk groups so that doctors can more accurately determine the course of care and whether to watch and wait, take a biopsy, or start treatment immediately.
“If this test was to be used in the clinic, large numbers of men could avoid an unnecessary initial biopsy and the repeated, invasive follow-up of men with low-risk disease could be drastically reduced.”
Dr. Jeremy Clark