ALS, or amyotrophic lateral sclerosis, is a progressive neurodegenerative disorder affecting the motor neurons in the central nervous system. The early symptoms of ALS include muscle twitching or cramps, weakness or stiffness in the limbs, and difficulty walking, speaking, or swallowing.
As ALS progresses, the muscles weaken until they ultimately become paralyzed, and the person cannot move or breathe. Individuals may also experience cognitive changes, such as memory loss or issues with their problem-solving skills.
There is currently no known cure for the condition, so people must be aware of the early symptoms of the condition and seek medical attention as soon as possible. Early diagnosis and treatment can help slow the progression of ALS, reduce symptoms, and improve quality of life.
This article explains the early symptoms of ALS, along with its treatment approaches, diagnosis, and outlook.
ALS is a progressive disease, meaning that its symptoms worsen over time. The early symptoms can vary from person to person but often
- muscle twitches in the hands, arms, legs, or tongue
- muscle cramps
- muscular stiffness
- weakness in an arm, leg, or the neck
- slurred speech
- problems chewing or swallowing
If someone experiences symptoms of ALS, it is important to speak with a doctor as soon as possible. A prompt diagnosis is crucial, as it allows for earlier treatment, which can help slow the progression of the disease.
Although experiencing these symptoms can be worrying, it is important to remember that ALS is rare, and many other conditions have similar symptoms. Consulting a doctor can help rule out any other potential causes of the symptoms and provide further information about diagnosing and treating ALS.
ALS is an umbrella term for a group of conditions that
As the motor neurons die, they cannot communicate with muscles, which causes the muscles to weaken, spasm and cramp, and waste away. Eventually, voluntary movements disappear, and the person becomes paralyzed.
ALS is a progressive condition with no cure, but treatments and therapies can help slow the progression of the disease.
ALS is challenging for doctors to diagnose, as no single test is sufficient for a formal diagnosis. Instead, healthcare professionals must perform a series of tests and assessments to rule out other conditions that cause similar symptoms before arriving at a diagnosis.
A comprehensive diagnostic workup
- Electrodiagnostic tests: These tests include electromyography and nerve conduction velocity, which indicate the health of the nerves and muscles.
- Blood and urine studies: These look for infections, metabolic abnormalities, and inflammation.
- Spinal tap: This tests for proteins relating to ALS or signs of infection or inflammation
- X-rays and other imaging studies: These imaging techniques identify compressed nerves or issues with the spinal cord.
- Muscle and nerve biopsies: These look for signs of damage or disease.
- Neurological examinations: These assess a person’s strength, reflexes, and coordination
Once the doctor has these results, they may refer the person to a neurologist or ALS specialist for further evaluation and diagnosis.
Experts do not fully understand what causes ALS, but it seems that various molecular issues contribute. These include:
- problems with protein balance, folding, and transport, producing inactive proteins in the body that can result in diseases
- exaggerated nerve stimulation
- oxidative stress, which can damage cells in the body
- inflammation of the neurons
- dysfunction of the mitochondria within cells, which can lead to diseases
Ultimately, these issues lead to damage and death of motor neurons and the symptoms of ALS.
It is not clear why certain people develop ALS, but there are several risk factors,
- Age: ALS is most common in people aged 55 to 75 years.
- Biological sex: Males are slightly more at risk for ALS, but this difference disappears with age.
- Race: Caucasian and non-Hispanic people are most at risk for ALS.
- Family history: Around 5 to 10% of ALS cases are due to genetic inheritance. More than a dozen gene mutations lead to inherited ALS.
- Military status: Military veterans have up to twice the risk of developing ALS compared with non-veterans, and although experts are unclear why, toxin exposure is one theory.
People with ALS typically experience worsened symptoms over 2 to 5 years after their diagnosis. However, everyone is different, and 1 in 5 individuals live for more than 5 years, while around 1 in 20 individuals live for 20 years or more.
Although ALS is a life changing diagnosis with serious consequences, early diagnosis and treatment can help people manage the symptoms and improve their quality of life. With advances in medical technology and
ALS is a progressive neurological condition that affects motor neurons in the brain and spinal cord. Its early symptoms, such as muscle weakness and cramps, vary from person to person, but anyone who experiences them should speak with a doctor. Although there is no cure for ALS, prompt diagnosis enables early treatment that can help slow disease progression.
Experts do not understand why some people develop ALS, but risk factors include age, biological sex, race, family history, and military service.
Although ALS is a serious and challenging condition, the outlook is improving with advances in medical technology and new treatments.